{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:21:49Z","timestamp":1791566509669,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08\u2010AR0777032"],"award-info":[{"award-number":["K08\u2010AR0777032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015629","name":"Jerome L. Greene Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous, systemic autoimmune diseases characterized by specific clinical features and, frequently, skeletal muscle inflammation. Specific subtypes of IIMs can be characterized by myositis\u2010specific autoantibodies and are associated with distinct clinical phenotypes. Here, we focus on anti\u2010melanoma differentiation\u2010associated protein 5 (MDA5)\u2013positive myositis and anti\u2010signal recognition particle (SRP)\u2010positive myositis, both of which exhibit seasonality but lack known environmental triggers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed Phage ImmunoPrecipitation Sequencing to profile serum antibodies against the human proteome, the human virome, and a comprehensive enterovirus library. We analyzed sera from 57 patients with anti\u2010MDA5 autoantibodies and 57 patients with anti\u2010SRP autoantibodies, as well as 57 healthy controls. All groups were matched for age, sex, and race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our autoantibody profiling results define specific immunogenic regions within the MDA5 and SRP autoantigens. We also discovered that in MDA5 sera, versus SRP sera, there was an elevated antibody response to the viral capsid protein 1 (VP1) of enterovirus B, which was accompanied by a decreased antibody response to rhinovirus A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considering the role of MDA5 as a sensor of picornaviral infections and a mediator of inflammatory signaling, our data suggest a novel etiologic link between enterovirus infection and anti\u2010MDA5 dermatomyositis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11752","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T11:39:32Z","timestamp":1730979572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comprehensive Enteroviral Serology Links Infection and Anti\u2010Melanoma Differentiation\u2010Associated Protein 5 Dermatomyositis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3413-2530","authenticated-orcid":false,"given":"Sahana","family":"Jayaraman","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-870X","authenticated-orcid":false,"given":"Eleni","family":"Tiniakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Morgenlander","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3700-859X","authenticated-orcid":false,"given":"Miso","family":"Na","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7150-7306","authenticated-orcid":false,"given":"Lisa","family":"Christopher\u2010Stine","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-196X","authenticated-orcid":false,"given":"H. Benjamin","family":"Larman","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.56"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.41"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2598"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.48"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-eular.1949"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001202"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102788"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.837024"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3547"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.4.420"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341108"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0025-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.773352"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01737-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113936"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330908"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu289"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313166"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.052191"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01802-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.08.007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.1728"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.11.153"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-001684"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa0698"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1856"},{"issue":"379","key":"e_1_2_7_32_1","first-page":"1","article-title":"Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes","volume":"12","author":"Monaco DR","year":"2021","journal-title":"Nat Commun"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.05.002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197502132920706"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197502202920807"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615990113"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_7_38_1","unstructured":"MorgenlanderW LarmanHB.GitHub \u2010 wmorgen1\/ARscore. March8 2023. Accessed May 2 2023.https:\/\/github.com\/wmorgen1\/ARscore"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049461\u20100"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103747"},{"key":"e_1_2_7_41_1","unstructured":"Sie B. GitHub \u2010 brandonsie\/phipcc: Case\u2010control reports for PhIP\u2010Seq. April 29 2019. Accessed June 10 2023.https:\/\/github.com\/brandonsie\/phipcc"},{"key":"e_1_2_7_42_1","volume-title":"A Novel Pipeline for Library Design and Deconvolution of Genus\u2010Wide Viral Epitope Reactivity Profiling","author":"Na M.","year":"2022"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15274"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.740154"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.937667"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-022-05149-6"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead397"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead550"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu436"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.05.010"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-215004"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04398-2"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21992"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.11.006"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1101\/285916"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.6.885"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_2_7_58_1","volume-title":"November","author":"The Human Protein Atlas","year":"2016"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000187"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721159115"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.751341"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.108"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00435-x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10020058"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.11.013"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212149"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5030"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.353557"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102024\u2010225773"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34145-4"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1151695"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.048"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.11752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:26:09Z","timestamp":1759418769000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.11752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/acr2.11752"],"URL":"https:\/\/doi.org\/10.1002\/acr2.11752","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"2024-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11752"}}