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Follow\u2010up was up to 48 weeks. Adipokines were measured in plasma at baseline with enzyme\u2010linked immunosorbent assay. The primary outcome for this report was the difference in remission (Clinical Disease Activity Index [CDAI] \u22642.8) over 48 weeks stratified by median adipokine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, levels of adiponectin and leptin were not associated with markers of RA activity, whereas participants with higher resistin levels had higher C\u2010reactive protein (CRP) levels, swollen joint count, and Disease Activity Score in 28 joints based on CRP compared to participants with lower resistin. Overall, participants with baseline adipokine levels above the median and those with adipokine levels below the median had similar mean CDAI and changes in CDAI throughout follow\u2010up for up to 48 weeks. Adjusted Cox proportional hazards models did not show any effect of baseline adiponectin, leptin, and resistin levels on the likelihood of achieving CDAI remission (adiponectin: hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.80\u20131.45, <jats:italic>P<\/jats:italic> = 0.62; leptin: HR 0.89, 95% CI 0.64\u20131.26, <jats:italic>P<\/jats:italic> = 0.52; resistin: HR 0.86, 95% CI 0.65\u20131.13, <jats:italic>P<\/jats:italic> = 0.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baseline adiponectin, leptin, and resistin levels are not associated with the likelihood of achieving CDAI remission over 48 weeks of treatment in a large cohort of people with untreated early RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11756","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T22:14:38Z","timestamp":1730758478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis"],"prefix":"10.1002","volume":"7","author":[{"given":"Georgios K.","family":"Vasileiadis","sequence":"first","affiliation":[{"name":"University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-2853","authenticated-orcid":false,"given":"Tahzeeb","family":"Fatima","sequence":"additional","affiliation":[{"name":"University of Gothenburg  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University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marte S.","family":"Heiberg","sequence":"additional","affiliation":[{"name":"University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete Lund","family":"Hetland","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Glostrup, Denmark, and University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-1934","authenticated-orcid":false,"given":"Michael","family":"Nurmohamed","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centers and Amsterdam Rheumatology and Immunology Center  Amsterdam The 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