{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:38:04Z","timestamp":1793151484485,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007949","name":"Reumatikerf\u00f6rbundet","doi-asserted-by":"publisher","award":["R\u2010566411"],"award-info":[{"award-number":["R\u2010566411"]}],"id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010342","name":"Gillbergska stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We have previously shown that HLA\u2010B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA). We now aimed to study the associations of HLA\u2010B27 with clinical features and disease outcomes 18 years after the onset of JIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 434 patients from the population\u2010based Nordic JIA cohort. Demographic and clinical data, including remission status, were collected consecutively at baseline, eight years after disease onset, and 18 years after disease onset and presented in relation to HLA\u2010B27 status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HLA\u2010B27 status was available for 416 of the 434 participants (96%) and was positive for 93 participants (22.4%), more often in men (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01). The sacroiliac, hips, and subtalar joints were more frequently involved in individuals who were HLA\u2010B27 positive than in individuals who were HLA\u2010B27 negative. In almost half of the individuals with HLA\u2010B27 positivity and uveitis, the uveitis was asymptomatic. Uveitis, inflammatory back pain, sacroiliitis, arthritis in hip, tarsal, and subtalar joints, and enthesitis during the disease course were all associated with a lower rate of remission off medication. HLA\u2010B27 positivity was significantly associated with a higher risk of not being in remission off medication after 18 years (odds ratio [OR] 2.6), especially in men (OR 5.6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical features related to spondylarthropathies were more common in patients who were HLA\u2010B27 positive and associated with worse outcomes and nonremission 18 years after disease onset, particularly in men. Our results underline the adverse impact of having HLA\u2010B27 positivity on long\u2010term outcomes in individuals with JIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.70005","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T03:41:35Z","timestamp":1742701295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Impact of\n                    <scp>HLA<\/scp>\n                    \u2010\n                    <scp>B27<\/scp>\n                    on Juvenile Idiopathic Arthritis: Eighteen Years of Follow\u2010up in the Population\u2010Based Nordic Juvenile Idiopathic Arthritis Cohort"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-3779","authenticated-orcid":false,"given":"Maria","family":"Ekelund","sequence":"first","affiliation":[{"name":"Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-8964","authenticated-orcid":false,"given":"Agnes","family":"Szentpetery","sequence":"additional","affiliation":[{"name":"Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-5198","authenticated-orcid":false,"given":"Ellen D.","family":"Arnstad","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology, Trondheim, and Levanger Hospital  Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto","sequence":"additional","affiliation":[{"name":"New Children's Hospital, Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Fasth","sequence":"additional","affiliation":[{"name":"Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-9908","authenticated-orcid":false,"given":"Mia","family":"Glerup","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Myrup","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Nordal","sequence":"additional","affiliation":[{"name":"UiT The Arctic University of Norway and University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marite","family":"Rygg","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology and St. Olavs Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Rypdal","sequence":"additional","affiliation":[{"name":"UiT The Arctic University of Norway and University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillemor","family":"Berntson","sequence":"additional","affiliation":[{"name":"Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00332-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120602"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27561"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"390","article-title":"International League of Associations for Rheumatology. 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