{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:14:15Z","timestamp":1791828855824,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This post hoc analysis evaluated change from baseline (\u0394) in weight\/body mass index (BMI) and association with disease activity or lipid changes in tofacitinib\u2010treated patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data up to month 12 were pooled from eight phase 3 and 3b\/4 studies of patients with RA receiving tofacitinib 5 or 10 mg twice daily or tofacitinib 11 mg modified\u2010release once daily (alone or combined with conventional synthetic disease\u2010modifying antirheumatic drugs), or placebo. Assessments included \u0394weight\/BMI and the proportion of patients with weight gain \u22655%, at months 3, 6, and 12. Correlations between \u2206weight\/\u2206BMI and baseline\/\u2206Disease Activity Score in 28 joints, erythrocyte sedimentation rate (DAS28\u20104[ESR]), baseline C\u2010reactive protein (CRP), and \u2206lipids were assessed. Statistical analysis included a longitudinal linear mixed model for repeated measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 5,335 patients (tofacitinib 5 mg twice daily [n = 2,349], 10 mg twice daily [n = 1,611], 11 mg once daily [n = 694], and placebo [n = 681]). Increases in least squares mean \u0394weight and \u0394BMI were significantly greater (<jats:italic>P<\/jats:italic> &lt; 0.05) at months 3 and 6 with all tofacitinib doses versus placebo; increases continued to month 12. Significantly greater (at least <jats:italic>P<\/jats:italic> &lt; 0.05) proportions of tofacitinib\u2010treated patients (all doses) had weight gain \u22655% at months 3 and 6 versus placebo. There were weak correlations between weight\/BMI changes with tofacitinib and DAS28\u20104(ESR), baseline CRP, or lipid changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients receiving tofacitinib experienced weight and BMI changes (primarily increases) over time, with weak correlations with disease activity or lipids.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.70040","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:56:10Z","timestamp":1746766570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of the Impact of Tofacitinib Treatment on Weight and Body Mass Index in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"7","author":[{"given":"J\u00fcrgen","family":"Wollenhaupt","sequence":"first","affiliation":[{"name":"Struenseehaus Centre for Rheumatology and Clinical Immunology  Hamburg 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