{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:44:07Z","timestamp":1759452247134,"version":"build-2065373602"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Beh\u00e7et disease (BD) is characterized by recurrent oral and genital ulcers, skin lesions, and vascular involvement. Giant aortic aneurysm, a life\u2010threatening complication of BD, often proves refractory to conventional therapies. Here, we present the case of a 71\u2010year\u2010old man with a 40\u2010year history of BD complicated by a giant aortic aneurysm, which was successfully managed using the interleukin\u20106 (IL\u20106) receptor antagonist tocilizumab (TCZ). Despite years of tight treatment with high\u2010dose glucocorticoids and immunosuppressants, there were frequent flares of disease and aortic aneurysm formation. Following the initiation of TCZ therapy, the patient achieved remarkable clinical improvement: the aortic aneurysm diameter decreased significantly from 10.15 \u00d7 7.83 cm to 6.22 \u00d7 5.12 cm, and disease activity, as measured by the Beh\u00e7et's Disease Current Activity Form score, dropped from 8 to 1, indicating sustained disease control. This case underscores the potential of IL\u20106 inhibition as a transformative therapeutic strategy for refractory BD with severe vascular complications, offering new hope for patients with this challenging condition.<\/jats:p>","DOI":"10.1002\/acr2.70071","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T19:44:15Z","timestamp":1751571855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Aortic Aneurysm in Refractory Beh\u00e7et\u2019s Disease Shrank with Tocilizumab Treatment: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-0595","authenticated-orcid":false,"given":"Zi\u2010Yi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital, and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Yi","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People's Hospital, and Thoracic Oncology Institute &amp; Research Unit of Intelligence Diagnosis and Treatment in Early Non\u2010small Cell Lung Cancer Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital, and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University People's Hospital, and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan\u2010Guo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People's Hospital Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, and Peking\u2010Tsinghua Center for Life Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000497"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab780"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.123145"},{"key":"e_1_2_1_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152153"},{"key":"e_1_2_1_6_6_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/9ipkcs"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:30:17Z","timestamp":1759415417000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/acr2.70071"],"URL":"https:\/\/doi.org\/10.1002\/acr2.70071","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"type":"print","value":"2578-5745"},{"type":"electronic","value":"2578-5745"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70071"}}