{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:48:38Z","timestamp":1759452518325,"version":"build-2065373602"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Here, we describe a rare presentation of eosinophilic granulomatosis with polyangiitis (EGPA) under benralizumab therapy manifesting as bilateral central retinal artery occlusion (CRAO). The patient, a 61\u2010year\u2010old man with chronic eosinophilic rhinosinusitis and severe asthma, experienced sudden bilateral visual loss and transient amaurosis. Ophthalmologic evaluations, including a fundus examination and optical coherence tomography, confirmed CRAO, and laboratory test results revealed elevated markers of inflammation and positive antimyeloperoxidase antibodies in the context of normal eosinophil counts. Intensive immunosuppressive therapy led to resolution of systemic inflammation, although significant visual impairment persisted. These findings underscore the potential limitations of anti\u2013interleukin\u20105 receptor therapy in preventing vasculitic complications in EGPA.<\/jats:p>","DOI":"10.1002\/acr2.70073","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:00:08Z","timestamp":1748991608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Eosinophilic Granulomatosis With Polyangiitis Despite Anti\u2013Interleukin\u20105 Receptor Therapy: The First Case of Bilateral Central Retinal Artery Occlusion During Benralizumab Treatment"],"prefix":"10.1002","volume":"7","author":[{"given":"Elena","family":"Treppo","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine University of Udine, Azienda Sanitaria Universitaria del Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Finocchio","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Azienda Sanitaria Universitaria del Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Fazzi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine University of Udine, Azienda Sanitaria Universitaria del Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pillon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine University of Udine, Azienda Sanitaria Universitaria del Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Quartuccio","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine University of Udine, Azienda Sanitaria Universitaria del Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_1_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.007"},{"key":"e_1_2_1_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803537"},{"issue":"3","key":"e_1_2_1_9_4_1","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.kint.2023.10.008","article-title":"Improving Global Outcomes (KDIGO) ANCA Vasculitis Work Group. KDIGO 2024 clinical practice guideline for the management of antineutrophil cytoplasmic antibody (ANCA)\u2010associated vasculitis","volume":"105","author":"Disease Kidney","year":"2024","journal-title":"Kidney Int"},{"key":"e_1_2_1_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.254"},{"key":"e_1_2_1_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223764"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:26:06Z","timestamp":1759422366000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/acr2.70073"],"URL":"https:\/\/doi.org\/10.1002\/acr2.70073","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"type":"print","value":"2578-5745"},{"type":"electronic","value":"2578-5745"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70073"}}