{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:05:57Z","timestamp":1773270357366,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P50 AR060780"],"award-info":[{"award-number":["P50 AR060780"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the physical, emotional, and mental impact of regular audio\u2010guided imagery (AGI) in patients with connective tissue disease (CTD)\u2013associated Raynaud phenomenon (RP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen adult patients with CTD\u2010associated RP were enrolled in an open\u2010label, single\u2010arm, eight\u2010week intervention with daily AGI at a single center. Patients completed surveys, including assessment of RP severity, depression\/anxiety, and quality of life at baseline and the end of eight weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Study participants demonstrated significant improvement in all patient reported outcomes, except Generalized Anxiety Disorder 7, which showed improvement but was not statistically significant. This eight\u2010week intervention shows that patients with CTD\u2010associated RP had less severe RP episodes, as well as improved quality of life and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AGI significantly improved several domains of health, including physical, emotional, and mental, in patients with CTD\u2010associated RP who otherwise more commonly struggle with more RP attacks, lower quality of life, and depression. AGI is a low\u2010cost, low\u2010risk, and convenient therapy for CTD\u2010associated RP. A larger study studying the effects of this intervention is indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.70074","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:05:24Z","timestamp":1753783524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Audio\u2010Guided Imagery on Raynaud Phenomenon in Connective Tissue Disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9548-5263","authenticated-orcid":false,"given":"Cristina","family":"Padilla","sequence":"first","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Katikineni","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongseok","family":"Park","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Freno","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Arthritis and Autoimmunity Center  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Laffoon","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Reichbaum","sequence":"additional","affiliation":[{"name":"University of Pittsburgh and University of Pittsburgh Medical Center Shadyside Hospital  Pittsburgh 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