{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:56:36Z","timestamp":1784796996224,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Still's disease is a complex, multisystemic disorder requiring prompt diagnosis and treatment. This study provides a general assessment of a Still's disease cohort aiming to evaluate the efficacy of early intervention with interleukin\u20101 inhibitors (IL\u20101i) in achieving clinical inactive disease (CID) and reducing glucocorticoid use in patients with Still's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 42 adult patients diagnosed with Still's disease after 2010 and treated with IL\u20101i. Patients were categorized as early treated (IL\u20101i started before six months from symptom onset) or late treated (IL\u20101i started after 6 months). CID achievement, glucocorticoid use, flares, and imaging findings were assessed. The chi\u2010square test was employed as a statistical test, and\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05 was considered significant. GraphPad Prism 8 was used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median time from symptom onset to IL\u20101i introduction was six months (interquartile range: 2\u201019). Overall, 55% of patients achieved CID at six months. Early treated patients showed a trend toward higher proportion of CID achievement compared to that of late\u2010treated patients (67% vs 38%;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.17). A meta\u2010analysis including our cohort and two other observational studies showed that early treatment was associated with an odds ratio of 6.73 (95% confidence interval: 2.31\u201319.64) in comparison to late treatment. All our patients initially received glucocorticoids, with 48% of those achieving CID able to discontinue glucocorticoids within six months. Ten major flares were observed, with 62% occurring after IL\u20101i suspension or spacing. At baseline, F\u2010fluorodeoxyglucose positron emission tomography (PET)\u2013computed tomography (CT) or magnetic resonance (MR) scans revealed hypermetabolic areas primarily in the bone marrow, spleen, and lymph nodes. After IL\u20101i introduction, these hypermetabolic regions generally showed a reduction in activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early introduction of IL\u20101i in patients with Still's\u00a0disease may lead to higher rates of CID achievement and glucocorticoid discontinuation. PET\u2010CT\/MR imaging may be valuable in assessing disease activity and guiding treatment decisions. These findings support the concept of a \u201cwindow of opportunity\u201d in Still's disease management, emphasizing the importance of prompt diagnosis and treatment initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.70106","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:24:56Z","timestamp":1759479896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early\n                    <scp>IL<\/scp>\n                    \u20101 Inhibition in Still's Disease: A Window of Opportunity for Improving Outcomes"],"prefix":"10.1002","volume":"7","author":[{"given":"Sara","family":"Bindoli","sequence":"first","affiliation":[{"name":"Department of Medicine, DIMED University of Padova  Padova Italy"},{"name":"Rheumatology Unit University Hospital of Padova  Padova 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