{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:12:38Z","timestamp":1773706358058,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI085567"],"award-info":[{"award-number":["R01AI085567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      T cell receptor \u03b1\u03b2\n                      <jats:sup>+<\/jats:sup>\n                      (TCR\u03b1\u03b2\n                      <jats:sup>+<\/jats:sup>\n                      ) CD4\n                      <jats:sup>\u2212<\/jats:sup>\n                      CD8\n                      <jats:sup>\u2212<\/jats:sup>\n                      double\u2010negative (DN) T cells are expanded in lupus\u2010prone mice and patients with systemic lupus erythematosus (SLE), produce interleukin\u201017 (IL\u201017), and contribute to disease pathogenesis. However, it is not known whether there is functional heterogeneity within this population. This study aimed to determine whether a subset of DN T cells produces IL\u201010 and whether the ratio of IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      \/IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cells correlates with disease activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Flow cytometry was used to analyze DN T cells in lupus\u2010prone MRL\/\n                      <jats:italic>lpr<\/jats:italic>\n                      mice and patients with SLE. IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      and IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cells were identified and quantified in the peripheral blood and lymphoid organs. Correlations between the IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      \/IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cell ratio and clinical parameters, including the SLE Disease Activity Index (SLEDAI) and proteinuria, were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      DN T cells were increased in lupus\u2010prone mice, whereas IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cells decreased in aging MRL\/\n                      <jats:italic>lpr<\/jats:italic>\n                      mice. In patients with SLE (n = 67), the IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      \/IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cell ratio was associated with higher SLEDAI scores and was elevated in those with proteinuria. A longitudinal analysis of patients with SLE similarly showed a positive correlation between SLEDAI scores and the IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      \/IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cell ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The observation of nonoverlapping IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      and IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      DN T cells suggests heterogeneity within the DN T cells in both lupus\u2010prone mice and patients. The IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      \/IL\u201010\n                      <jats:sup>+<\/jats:sup>\n                      DN T cell ratio may serve as a biomarker to monitor disease activity in patients with SLE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.70108","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T06:29:58Z","timestamp":1760336998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>IL<\/scp>\n                    \u201017\n                    <sup>+<\/sup>\n                    \/\n                    <scp>IL<\/scp>\n                    \u201010\n                    <sup>+<\/sup>\n                    Ratio in\n                    <scp>TCR\u03b1\u03b2<\/scp>\n                    <sup>+<\/sup>\n                    <scp>CD4<\/scp>\n                    <sup>\u2212<\/sup>\n                    <scp>CD8<\/scp>\n                    <sup>\u2212<\/sup>\n                    T Cells As a Marker of Disease Activity in Lupus\u2010Prone Mice and Patients With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"7","author":[{"given":"Rui","family":"Imai","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwesha","family":"Kar","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston 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