{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:45:57Z","timestamp":1769741157964,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlation and association between dynamic contrast\u2013enhanced magnetic resonance imaging (DCE\u2010MRI) quantification (DEMRIQ) parameters with local and systematic markers of inflammation in patients with various etiologies of acute knee arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cross\u2010sectional setting, patients with symptoms of acute knee arthritis underwent DCE\u2010MRI, and DEMRIQ parameters were acquired. Markers of inflammation were obtained from the blood and synovial fluid through ultrasound\u2010guided arthrocentesis of the affected joint. Spearman correlation and linear regression were performed to assess the correlation and association between DEMRIQ parameters and markers of inflammation, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one patients, including 12 with rheumatoid factor\u2013positive rheumatoid arthritis (RF+RA), 6 with rheumatoid factor\u2013negative RA (RF\u2212RA), 6 with psoriatic arthritis, 3 with reactive arthritis, and 14 with osteoarthritis (OA), were imaged. In the RF+RA group, all DEMRIQ variables correlated significantly with joint fluid interleukin\u20106 level (r \u2265 0.6) and number of neutrophils and polymorphonuclear (PMN) cells (r \u2265 0.8), whereas MExNvoxel and IRExNvoxel correlated with synovial inflammatory cells and blood C\u2010reactive protein (CRP) levels (r \u2265 0.6). In patients with RF\u2212RA, MExNvoxel correlated with blood CRP level (r = 0.8), joint fluid white blood cells, and neutrophils and PMN cells (r = 1). In the seronegative arthritis group, IRExNvoxel correlated with blood CRP, joint fluid PMN cells, and neutrophils (r \u2265 0.7). No significant correlation was seen in the OA group. There was a significant regression correlation between MExNvoxel and inflammatory infiltrates from joint fluid in RF+RA group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DEMRIQ parameters exhibit varying relationships with local synovial and systemic inflammatory blood biomarkers across different etiologies of knee arthritis, which could provide insight into the level of inflammation in the affected joint.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.70154","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:52:15Z","timestamp":1767952335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computer\u2010Assisted Dynamic Contrast\u2013Enhanced Magnetic Resonance Imaging Quantification Method for Assessment of Synovial Inflammation in Active Arthritis: Correlation With Synovial and Blood Biomarkers"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-6563","authenticated-orcid":false,"given":"M.","family":"Boesen","sequence":"first","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Radiology Copenhagen University Hospital  Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Image Analysis Group  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-4126","authenticated-orcid":false,"given":"D.","family":"Shakoor","sequence":"additional","affiliation":[{"name":"Hospital of Special Surgery  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kubassova","sequence":"additional","affiliation":[{"name":"Image Analysis Group  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Riis","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Copenhagen University Hospital  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-1668","authenticated-orcid":false,"given":"H.","family":"Bliddal","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ballegaard","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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