{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:25:18Z","timestamp":1791505518692,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) are effective cancer therapies but often cause serious immune\u2010related adverse events (irAEs). Patients with preexisting autoimmune diseases, including vasculitis, are excluded from trials. We aimed to evaluate the frequency, severity, and outcomes of vasculitis flares and irAEs in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of cancer patients with prior vasculitis treated with ICIs at our institution and conducted a literature search for additional cases. Data included baseline features, vasculitis flares, irAEs, treatments, and tumor response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five patients were identified (16 from our institution and 9 from the literature). Median age was 71 years; 13 (52%) were female. Vasculitis types included giant cell arteritis (GCA, n\u00a0=\u00a09), granulomatosis with polyangiitis (GPA, n\u00a0=\u00a08), eosinophilic granulomatosis with polyangiitis (EGPA, n\u00a0=\u00a02), leukocytoclastic vasculitis (n\u00a0=\u00a02), other cutaneous vasculitis (n\u00a0=\u00a02), and Henoch\u2013Sch\u00f6nlein purpura and Beh\u00e7et disease (1 each). Cancer types were diverse. Most patients received anti\u2013programmed death\u20101 monotherapy (n\u00a0=\u00a017). Eight patients (31%) experienced a vasculitis flare after ICI initiation (2\/9 GCA, 4\/8 GPA, 2\/4 cutaneous vasculitis). Flares occurred after a median of seven weeks. Treatment included glucocorticoids in seven patients, combined with biologic or cytotoxic agents depending on vasculitis type. Seven of eight flares resolved, and four patients continued ICI therapy. Three additional patients developed de novo irAEs: severe hepatitis (n\u00a0=\u00a01), grade 3 colitis (n\u00a0=\u00a01), and grade 3 autoimmune hemolytic anemia (n\u00a0=\u00a01), all improving with treatment. One patient with GCA died due to a flare; no deaths were attributed to de novo irAEs. Overall, more than one\u2010third of patients achieved a favorable tumor response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nearly one\u2010third of patients with preexisting vasculitis experienced a disease flare during ICI therapy, with one fatal case. For most, outcomes were favorable with effective flare management. Preexisting vasculitis should not be considered an absolute contraindication for cancer immunotherapy with ICI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90003","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:11:23Z","timestamp":1773015083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety of Immune Checkpoint Inhibitors in Cancer Patients With Preexisting Autoimmune Vasculitis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7813-2747","authenticated-orcid":false,"given":"Juan","family":"Sevillano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, McGovern Medical School University of Texas Health Science Center  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Department of 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-5797","authenticated-orcid":false,"given":"Maria E.","family":"Suarez\u2010Almazor","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology University of Texas MD Anderson Cancer Center  Houston"},{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center  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