{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:51:12Z","timestamp":1775893872576,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR076316"],"award-info":[{"award-number":["P30AR076316"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR084717"],"award-info":[{"award-number":["R01\u2010AR084717"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32 AR069516"],"award-info":[{"award-number":["T32 AR069516"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","award":["344848.01.01.2024365.10"],"award-info":[{"award-number":["344848.01.01.2024365.10"]}],"id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The physician global assessment of lung disease (PGALD) is a recently proposed disease activity measure for patients with systemic juvenile idiopathic arthritis\u2013associated lung disease (SJIA\u2010LD). This study evaluates the reliability and construct validity of the PGALD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010seven pediatric rheumatologists and pulmonologists with experience caring for children with SJIA\u2010LD were invited to rate 20 clinical vignettes using the PGALD, a 10\u2010point Likert scale (0 = inactive SJIA\u2010LD; 10 = highly active SJIA\u2010LD). Raters were also asked to rate a subset of eight repeat vignettes. Interrater and intrarater reliability were assessed using intraclass correlation coefficients (ICCs), whereas SJIA\u2010LD features influencing PGALD ratings were assessed using univariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ICC for all raters was 0.68 (95% confidence interval [CI] 0.54\u20130.82), indicating moderate to good interrater reliability. The retest ICC was 0.86 (95% CI 0.82\u20130.89), indicating good intrarater reliability. Factors associated with higher mean PGALD scores included the presence of crackles on auscultation (5.7 vs 2.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001), hypoxemia on pulse oximeter (5.6 vs 3.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01), current oxygen requirement (6.3 vs 3.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04), suggestive diagnostic imaging features (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.01), and three or more prescribed medications for SJIA\u2010LD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.01). Pulmonary function measures demonstrated significant negative correlations with PGALD scores: forced vital capacity (r\u00a0=\u00a0\u22120.71;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01), total lung capacity (r\u00a0=\u00a0\u22120.92;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01), and lung diffusion capacity (r\u00a0=\u00a0\u22120.97;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0002). Only C\u2010reactive protein was weakly to moderately correlated with PGALD scores (r\u00a0=\u00a00.39;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.09), whereas other laboratory markers (ferritin, interleukin 18, CXCL9, and sIL\u20102R) were not significantly correlated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PGALD is a novel measure of SJIA\u2010LD activity. Its initial validation suggests acceptable construct validity and reliability. Additional studies are needed to assess its responsiveness to change over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90006","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:10:51Z","timestamp":1773033051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliability and Construct Validity of the Physician's Global Assessment of Lung Disease in Systemic Juvenile Idiopathic Arthritis\u2013Associated Lung Disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8529-4830","authenticated-orcid":false,"given":"Eileen","family":"Rife","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihua","family":"Zhai","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Andringa","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-5337","authenticated-orcid":false,"given":"Scott","family":"Canna","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-4029","authenticated-orcid":false,"given":"Lauren A.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital and Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-3390","authenticated-orcid":false,"given":"Yukiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Hackensack Meridian School of Medicine  Nutley New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"University of Iowa  Iowa City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Riskalla","sequence":"additional","affiliation":[{"name":"University of Minnesota  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Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-7051","authenticated-orcid":false,"given":"Grant","family":"Schulert","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio"},{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the PGALD Validation Consortium 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