{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:25:01Z","timestamp":1783463101928,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage, affecting women between the ages of 15 and 45 years at a 9:1 rate as compared to men. The etiology of SLE is complex and elusive; however, the susceptibility of women during the years in which estrogen levels are at their highest suggests a significant contribution to the development of SLE. Previously, our group and others have shown that estrogen receptor \u03b1 (ER\u03b1) carrying immune cells are mediators of the proinflammatory effects of estrogen as compared to cells that lack this receptor. ER\u03b2, the other estrogen responsive transcription factor, has been postulated to have an antagonistic effect to ER\u03b1, which mediates the anti\u2010inflammatory effects of estrogen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the pursuit of a drug that is tailored to have a favorable selective estrogenic effect, The Ohio State University Drug Development Institute discovered a novel carborane\u2010based selective ER modulator, OSU\u2010ER\u03b2\u2010012. This ER\u03b2 agonist exhibits potent binding of human ER\u03b2 (Ki = 2.0 nM) and functional selectivity for ER\u03b2 over ER\u03b1 of at least 200\u2010fold. We tested the effectiveness of OSU\u2010ER\u03b2\u2010012 in treating lupus\u2010humanized NSG mice by examining serum for the presence of inflammatory cytokines and histopathology of hearts and kidneys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The humanized mice exhibited increased expression of inflammatory cytokines, pericarditis, and increased glomerular size, which were all mitigated by the treatment with OSU\u2010ER\u03b2\u2010012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OSU\u2010ER\u03b2\u2010012 is an effective therapeutic in this NSG mouse model with humanized SLE because it inhibits the proinflammatory renal and cardiac phenotype.<\/jats:p>\n                  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