{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:07:51Z","timestamp":1792454871803,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023446","name":"Scleroderma Association of British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019175","name":"Scleroderma Society of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The RNA\u2010binding region\u2010containing protein 3 (RNPC3) protein acts as a molecular bridge, promoting U11\/U12 RNP complex formation. In previous reports, patients with systemic sclerosis (SSc) with anti\u2010RNPC3 autoantibodies had an increased risk of interstitial lung disease (ILD), severe gastrointestinal (GI) disease, and cancer. The aim of this study was to compare phenotypic features of patients with mixed connective tissue disease (MCTD) with and without anti\u2010RNPC3 autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective MCTD cohort was studied. Addressable laser bead immunoassay was used to detect anti\u2010RNPC3 autoantibodies with &lt;1,000 mean fluorescence intensity (MFI) as normal reference range, 1,000 to 2,999 MFI as low\u2010titer positivity and \u22653,000 MFI as high\u2010titer positivity. Cancer occurrence within (\u00b1) five years of MCTD diagnosis and comparison of clinical features between anti\u2010RNPC3+ and anti\u2010RNPC3\u2212 subgroups were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen of 66 (23%) patients with MCTD were anti\u2010RNPC3+, which were associated with a higher frequency of sclerodactyly (anti\u2010RNPC3+ vs anti\u2010RNPC3\u2212: 100% vs 67%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007), but their frequency in ILD and GI involvement was similar (4 of 12, 33% vs 18 of 44, 41%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.73; and 13 of 14, 93% vs 43 of 46, 93%\n                      <jats:italic>P<\/jats:italic>\n                      = 0.91, respectively). Cancer was present in 3 of 15 (20%) anti\u2010RNPC3+ compared to 3 of 51 (5.9%) anti\u2010RNPC3\u2212 patients (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.13). Numerically, more malignancy was observed among patients with high\u2010titer anti\u2010RNPC3+ (unadjusted odds ratio 16.00, 95% confidence interval 0.54\u2013484.28,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010RNPC3 autoantibodies were associated with a higher frequency of SSc skin involvement in patients with MCTD. Anti\u2010RNPC3 autoantibodies, especially in high titers, might be the markers for an increased risk of cancer in MCTD that needs to be confirmed in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90035","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:24:25Z","timestamp":1775611465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Associations of Anti\u2010\n                    <scp>RNPC3<\/scp>\n                    Autoantibodies in Mixed Connective Tissue Disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-3563","authenticated-orcid":false,"given":"Darya S.","family":"Jalaledin","sequence":"first","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"El Kamouni","sequence":"additional","affiliation":[{"name":"Division of Rheumatology H\u00f4pital de la Cit\u00e9\u2010de\u2010la\u2010Sant\u00e9  Laval Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Albert","sequence":"additional","affiliation":[{"name":"Clinique Multidisciplinaire de Neuville  Neuville Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-5729","authenticated-orcid":false,"given":"Sabrina","family":"Hoa","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Bourr\u00e9\u2010Tessier","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rich","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Richard","family":"Goulet","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-1472","authenticated-orcid":false,"given":"Martial","family":"Koenig","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Autoimmunity Research Laboratory Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Research Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-2737","authenticated-orcid":false,"given":"May Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Troyanov","sequence":"additional","affiliation":[{"name":"Division of Rheumatology H\u00f4pital du Sacr\u00e9\u2010C\u0153ur de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-5105","authenticated-orcid":false,"given":"Minoru","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Medicine Kitakyushu Yahata\u2010Higashi Hospital  Kitakyushu Japan"},{"name":"Department of Human, Information and Life Sciences University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-6608","authenticated-orcid":false,"given":"Marvin J.","family":"Fritzler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2297-3765","authenticated-orcid":false,"given":"Jean\u2010Luc","family":"Sen\u00e9cal","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Autoimmunity Research Laboratory Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Research Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-6165","authenticated-orcid":false,"given":"Oc\u00e9ane","family":"Landon\u2010Cardinal","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec 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