{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:05:36Z","timestamp":1779444336342,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060302"],"award-info":[{"award-number":["82060302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260325"],"award-info":[{"award-number":["82260325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["24JRRA923"],"award-info":[{"award-number":["24JRRA923"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["25YFFA055"],"award-info":[{"award-number":["25YFFA055"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous studies by our research group demonstrated that interstitial lung disease (ILD) associated with idiopathic inflammatory myopathy (IIM) correlates with endothelial cell injury and neutrophil extracellular trap (NETs) formation. This study aimed to investigate the clinical relevance of serum endothelin\u20101 (ET\u20101) and NETs markers, such as cell\u2010free DNA (cfDNA), in IIM\u2010associated ILD (IIM\u2010ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral blood samples were collected from 60 patients with IIM (44 with dermatomyositis and 16 with polymyositis) and 20 healthy controls. Among the patients with IIM, 33 were diagnosed with ILD. Serum ET\u20101 and cfDNA levels were measured, and differences in ET\u20101 levels across groups, correlations between ET\u20101 and cfDNA, and diagnostic performance via logistic regression models and receiver operating characteristic (ROC) curves were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum ET\u20101 levels were significantly elevated in patients with IIM compared to healthy controls (10.89\u2009\u00b1\u20093.49 pg\/mL vs 2.09\u2009\u00b1\u20090.56 pg\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The subgroup with IIM\u2010ILD exhibited a 36.3% increase in ET\u20101 levels compared to the subgroup with IIM without ILD (12.17\u2009\u00b1\u20093.67 pg\/mL vs 9.34\u2009\u00b1\u20092.53 pg\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0012), with a positive correlation between ET\u20101 and cfDNA (r\u00a0=\u00a00.374,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003). Multivariate analysis identified ET\u20101 as an independent risk factor for ILD (odds ratio 1.442, 95% confidence interval 1.082\u20131.923). A combined model incorporating ET\u20101, albumin\u2013globulin ratio, lactate dehydrogenase, and complement C4 achieved an area under the ROC curve of 0.888 (sensitivity 78.8% and specificity 88.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum ET\u20101 levels were elevated in patients with IIM, particularly in those with ILD, suggesting its potential role in the pathogenesis and progression of IIM\u2010ILD.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr290044-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90044","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:42:52Z","timestamp":1776818572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Endothelin\u20101 Is Associated With Interstitial Lung Disease in Idiopathic Inflammatory Myopathy"],"prefix":"10.1002","volume":"8","author":[{"given":"Yun","family":"Lv","sequence":"first","affiliation":[{"name":"The Second Clinical Medical School, Lanzhou University  Lanzhou China"},{"name":"Department of Rheumatology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Lanzhou University  Lanzhou 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