{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:14:36Z","timestamp":1787764476183,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR084199"],"award-info":[{"award-number":["R01\u2010AR084199"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Career Development Bridge Funding Award"],"award-info":[{"award-number":["Career Development Bridge Funding Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There is a need for measures of disease severity for giant cell arteritis (GCA), which may enable identification of high\u2010risk subgroups (eg, ophthalmic complications) and individualized approaches to therapy. We derived a continuous score using data from cranial vessel wall magnetic resonance imaging (VW\u2010MRI) to quantify vascular burden in GCA and assessed the score's association with ophthalmic manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with suspected new or relapsing GCA underwent cranial VW\u2010MRI plus dedicated orbital MRI. A radiologist assessed VW\u2010MRI enhancement of seven cranial structures bilaterally. Using a generalized linear mixed\u2010effects model, a continuous MRI\u2010derived patient\u2010level score (range 1\u201310) of disease extent was developed: the Cranial Artery MRI Score for GCA (CAMRIS\u2010GCA). CAMRIS\u2010GCA was compared between clinical diagnosis (ocular GCA, nonocular GCA, or non\u2010GCA) and patients with versus without ocular inflammation on MRI (defined as ophthalmic artery or optic nerve sheath enhancement).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients (17 ocular GCA, 16 nonocular GCA, and 41 non\u2010GCA) were included. CAMRIS\u2010GCA increased linearly across clinically defined groups of non\u2010GCA, nonocular GCA, and ocular GCA (CAMRIS\u2010GCA median 0.6 [interquartile range (IQR) 0\u20131.7] vs median 2.5 [IQR 0.5\u20136.6] vs median 4.8 [IQR 2.1\u20138.5];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Patients with orbital inflammation on MRI (with or without visual symptoms) had a higher median CAMRIS\u2010GCA compared to patients with negative orbital MRI (median 6.7 [IQR 5.6\u20138.5] vs median 0.4 [IQR 0\u20131.6];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This proof\u2010of\u2010concept study introduces a quantitative MRI\u2010derived vascular burden score in GCA and demonstrates its association with ophthalmic involvement. These early findings suggest that cranial VW\u2010MRI may offer a prognostic value in identifying patients at risk for vision\u2010threatening disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90066","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:38:31Z","timestamp":1778056711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of Vascular Burden on Cranial Vessel Wall Magnetic Resonance Imaging and Ophthalmic Complications in Giant Cell Arteritis"],"prefix":"10.1002","volume":"8","author":[{"given":"David L.","family":"Yang","sequence":"first","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quy","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"McWilliams","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rebello","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, St. Joseph's Hospital McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura A.","family":"Tamhankar","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010ophthalmology, Scheie Eye Institute University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-1949","authenticated-orcid":false,"given":"Shubhasree","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia"},{"name":"Division of Rheumatology University 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