{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:47:07Z","timestamp":1782463627303,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","award":["126498"],"award-info":[{"award-number":["126498"]}],"id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide 1 receptor agonists (GLP\u20101RAs) facilitate weight loss and reduce pain among individuals with knee osteoarthritis (OA). We investigated attitudes and barriers influencing GLP\u20101RA use among individuals with knee OA and excess weight to draw distinctions in perspectives between patients with and without GLP\u20101RA experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional qualitative study guided by the Framework Analysis method, we conducted structured interviews with persons with knee OA and excess weight. The moderator's guide included questions about health, weight loss history, and thoughts and experiences related to GLP\u20101RAs. Of the 286 patients prescreened, 30 completed an interview, after which saturation was reached. Interview transcripts were coded by research assistants using Dedoose software, and themes were identified using inductive analysis, charting, and memo writing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 30 individuals interviewed were majority female and most self\u2010identified as White. Fifteen participants had current or prior GL\u2010P1RA use, and fifteen had\u00a0never taken GLP\u20101RAs. We identified four major themes: (1) health care providers were the primary GLP\u20101RA information source; (2) most participants recognized that weight loss could contribute to knee pain relief; (3) \u201cever users\u201d reported overall positive experiences and found GLPA\u20101RAs helped facilitate healthy lifestyle changes, whereas \u201cnever users\u201d more often described medications as a last resort after lifestyle changes fail; and (4) cost was the most significant barrier to GLP\u20101RA use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that perceptions both differed and overlapped among participants with and without prior GLP\u20101RA use. Clinicians should address potential concerns regarding GLP\u20101RAs when discussing treatment options with patients with excess weight and knee OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90070","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:29:57Z","timestamp":1781760597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perceptions of Glucagon\u2010like Peptide 1 Receptor Agonists Among Individuals With Knee Osteoarthritis and Excess Weight: A Qualitative Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9340-6939","authenticated-orcid":false,"given":"Kelly","family":"Frier","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Brigham and Women's Hospital  Boston 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