{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:39:05Z","timestamp":1792665545702,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe patient profiles, treatment patterns, clinical outcomes, and safety of intentional dual biologic or targeted synthetic disease\u2010modifying antirheumatic drug (b\/tsDMARD) therapy in psoriatic arthritis (PsA). A subset of patients with PsA continue to experience persistent inflammation despite b\/tsDMARD monotherapy. Dual b\/tsDMARD therapy has emerged as a potential strategy in refractory cases, but evidence in PsA remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nested study within the International Psoriasis and Arthritis Research Team prospective cohort. Adults satisfying Classification Criteria for Psoriatic Arthritis who received two concurrent b\/tsDMARDs (TNFi, IL\u201017i, IL\u201023i, JAKi, TYK2i, with or without apremilast) for \u226560 days were included. Baseline features, previous therapies, indications for dual therapy, and disease activity measures (tender joint count in 68 joints, swollen joint count in 66 joints, Disease Activity Index for Psoriatic Arthritis [DAPSA], Psoriasis Area and Severity Index [PASI], body surface area, patient visual analog scale) were collected. Clinical outcomes were reassessed at three\u2010 to six\u2010month intervals, with effectiveness assessed only for dual bDMARD + JAK\/TYK2i combinations. Safety was evaluated through all\u2010cause adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine patients initiated dual therapy: 24 patients received bDMARD + JAK\/TYK2i and 15 patients with bDMARD + apremilast. Patients were highly treatment\u2010experienced (median two conventional synthetic DMARDs and five b\/tsDMARDs). Indications included refractory peripheral arthritis, concurrent joint and skin activity, palmoplantar or nail psoriasis, and persistent enthesitis. Among bDMARD + JAK\/TYK2i combinations, improvements were observed in joint counts, DAPSA, PASI, and patient\u2010reported outcomes. Adverse events were infrequent and mild.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, dual b\/tsDMARD therapy was feasible, well\u2010tolerated, and associated with clinical improvement in patients with refractory PsA. These findings support its individualized use and highlight the need for controlled studies to define long\u2010term safety and optimal combination strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90084","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:45:41Z","timestamp":1786427141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Targeted Therapy as a Treatment Strategy for Refractory Psoriatic Arthritis: Real\u2010World Effectiveness and Safety From a Prospective Cohort"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-8924","authenticated-orcid":false,"given":"Andr\u00e9","family":"Lucas Ribeiro","sequence":"first","affiliation":[{"name":"Hospital Moinhos de Vento  Porto Alegre Brazil"},{"name":"Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre 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