{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:59:56Z","timestamp":1790236796637,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008319","name":"Fondation Arthritis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>FADD (Fas\u2010Associated Death Domain) protein in patients\u2019 serum and synovial fluid could be a biomarker of inflammation in rheumatic diseases. We tested whether the baseline serum FADD level would be a predictive factor for meeting the American College of Rheumatology (ACR)\/EULAR 2010 criteria for rheumatoid arthritis (RA) in order to facilitate the early diagnosis of RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured FADD by enzyme\u2010linked immunosorbent assay in the sera from 659 patients with early arthritis from the Etude et Suivi des Polyarthrites Indiff\u00e9renci\u00e9es R\u00e9centes (ESPOIR) cohort (at least two swollen joints for more than six weeks and less than six months, no previous exposure to glucocorticoids or disease\u2010modifying antirheumatic drugs). Patients were eligible for inclusion in the cohort if they had a definitive or probable clinical diagnosis of RA or a diagnosis of undifferentiated arthritis (UA) with a potential for progressing to RA, according to the 2010 ACR\/EULAR criteria for RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At inclusion, serum FADD protein was detected in 501 of 659 (76%) patients (range 0\u20131,503 ng\/mL) and levels were independent of patient age and sex. Statistically significant higher levels of FADD were detected in the serum from patients with diagnosed RA at inclusion or who were diagnosed with RA thereafter, than from patients with UA. Receiver operating characteristic curve analysis indicated that a FADD &gt;8 ng\/mL had the best sensitivity (50.95%) and specificity (85.71%) for the diagnosis of RA. Moreover, FADD levels were positively associated with anti\u2013citrullinated protein antibody (ACPA), rheumatoid factors, proinflammatory interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106 and IL\u20102, and APRIL, a marker of B lymphocyte activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline serum FADD level measurement appeared as a helpful biomarker for the early diagnosis of RA, particularly in patients who were ACPA negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90094","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:16:11Z","timestamp":1788758171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>FADD<\/scp>\n                    Protein for the Early Diagnosis of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"8","author":[{"given":"G\u00e9raldine","family":"Falgarone","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche SynKoMIC, Universit\u00e9 Sorbonne Paris Nord  Bobigny France"},{"name":"Unit\u00e9 de M\u00e9decine Ambulatoire, H\u00f4pital Avicenne, Assistance Publique \u2010 H\u00f4pitaux de Paris  Bobigny France"},{"name":"Institut F\u00e9d\u00e9ratif de Recherche Synerco, Universit\u00e9 Sorbonne Paris Nord  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mouasni","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1016, CNRS 8104, Cochin Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Mistou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1016, CNRS 8104, Cochin Institute  Paris 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