{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:59:18Z","timestamp":1785452358783,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR072999"],"award-info":[{"award-number":["AR072999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR073752"],"award-info":[{"award-number":["AR073752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR074992"],"award-info":[{"award-number":["AR074992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR080902"],"award-info":[{"award-number":["AR080902"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR083662"],"award-info":[{"award-number":["AR083662"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting joints marked by daily and intermittent surges in inflammatory cytokine levels that result in \u201cflares\u201d of disease activity. Because circadian proteins regulate inflammatory responses in arthritis, continuous behavioral\u2010 and tissue\u2010level monitoring may clarify therapeutic dynamics. Using the K\/BxN serum transfer arthritis (STA) mouse model, we tested whether locomotor activity and circadian clock gene expression track RA progression from onset through symptom resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6NJ and PER2::luciferase mice (8\u201310 weeks) received 180 \u03bcL K\/BxN serum via retroorbital injection. Uninjected littermates served as controls. We measured daily ankle thickness and continuously monitored open\u2010field locomotion from singly housed mice, a subset of which received dexamethasone (DEX) at dusk daily for 6 days. PER2::luciferase bioluminescence from paw, suprachiasmatic nuclei (SCNs), and femoral heads explants from mice treated with or without DEX were compared during STA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total daily locomotion decreased alongside ankle swelling approximately 2 days following K\/BxN STA. STA altered the timing of daily PER2 peak expression in arthritic paws but not in the SCN or nonarthritic joints. By day 22, total daily locomotion, ankle thickness, and paw circadian phase had resolved. In vivo DEX reduced circadian phase disruption in arthritic paws, accelerated the resolution of ankle swelling, and increased total daily locomotion without altering locomotor timing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Locomotor activity is a real\u2010time, noninvasive supplement for measuring RA onset and resolution. Altered PER2 expression indicates that local circadian synchrony in arthritic joints is impaired. DEX may aid recovery by resynchronizing circadian rhythms in arthritic tissues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90112","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:58:37Z","timestamp":1784602717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Circadian Clocks Are Desynchronized From the Central Circadian Pacemaker in a Mouse Model of Inflammatory Arthritis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-364X","authenticated-orcid":false,"given":"Lance A.","family":"Riley","sequence":"first","affiliation":[{"name":"Department of Biology Washington University  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E.","family":"Springer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Paola","family":"C\u00e1rdenas\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Biology Washington University  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Biology Washington University  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0330","authenticated-orcid":false,"given":"Farshid","family":"Guilak","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Washington University School of Medicine  St. Louis Missouri"},{"name":"Shriners Hospitals for Children St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-3699","authenticated-orcid":false,"given":"Christine T. N.","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik D.","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Biology Washington University  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11728"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39104"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.150"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099184"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00213"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojra.2014.41010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291399"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2337-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112781119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00576.2020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02643-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-29748-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20174797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2025-0784"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj8892"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.240089"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600353R"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12208"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr2.90112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:25:57Z","timestamp":1785450357000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.90112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/acr2.90112"],"URL":"https:\/\/doi.org\/10.1002\/acr2.90112","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e90112"}}