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The objective of this pilot study was to further characterize soft tissue properties that may be important to knee OA pain, and their associations with indicators of pain sensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two older adults (aged 50\u201385 years) with knee OA pain completed quantitative sensory testing (QST), myotonometry (ie, MyotonPRO) in the rectus femoris and biceps femoris, and clinical measures. Using data reduction techniques and unsupervised machine learning, we identified pain sensitivity profiles. Univariate and multivariate analyses of covariance examined associations between pain sensitivity profiles, muscle properties (stiffness, tone, decrement, relaxation time, and creep) and clinical pain, adjusted for age, sex, and body mass index. Pearson correlations assessed bivariate correlations between QST measures and muscle properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two profiles were identified: (1) high pain sensitivity or inefficient conditioned pain modulation (CPM) and (2) low pain sensitivity or efficient CPM and were significantly associated with muscle properties and clinical pain (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), such that those with low pain sensitivity demonstrated greater tone and stiffness, and lower relaxation time and creep.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using a brief QST battery, we identified two distinct pain sensitivity profiles that were differentially associated with periarticular tissue properties. Our results align with recent findings demonstrating distinct pain phenotypes in knee OA and that periarticular tissues may be important to understanding pain variability in knee OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90118","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:12:06Z","timestamp":1786021926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain Sensitivity Profiles Are Associated With Muscle Biomechanics and Clinical Pain in Persons With Symptomatic Knee Osteoarthritis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-8703","authenticated-orcid":false,"given":"Alisa J.","family":"Johnson","sequence":"first","affiliation":[{"name":"Pain Research Center National Center for Complementary &amp; Integrative Health, National Institutes of Health  Bethesda Maryland"},{"name":"Pain Research &amp; 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