{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:39:48Z","timestamp":1789468788402,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24AR078950"],"award-info":[{"award-number":["K24AR078950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate for possible association between\n                      <jats:italic>HLA\u2010B<\/jats:italic>\n                      genotype and disease phenotype in children with juvenile spondyloarthritis (JSpA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross\u2010sectional retrospective study of children evaluated at a large tertiary care rheumatology clinic. Inclusion criteria were (1) fulfillment of criteria for juvenile idiopathic arthritis (JIA) subtypes: enthesitis\u2010related arthritis (ERA), psoriatic arthritis (PsA), or undifferentiated JIA (ERA criteria plus a first\u2010degree relative with psoriasis); or (2) a diagnosis of inflammatory bowel disease\u2010associated arthritis (IBD\u2010AA); or (3) magnetic resonance imaging\u2010confirmed inflammatory sacroiliitis in patients who did not meet JIA subtype criteria. All children underwent complete HLA\u2010B testing. Comparisons of\n                      <jats:italic>HLA\u2010B<\/jats:italic>\n                      allele frequencies between JSpA and a published national cohort were conducted through two\u2010sample tests of proportions and controlled for multiple testing using the Benjamini\u2013Hochberg procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 150 children who met the inclusion criteria, and 28% (42 of 150) were\n                      <jats:italic>HLA\u2010B*27<\/jats:italic>\n                      \u2010positive. Overall, participants exhibited pronounced heterogeneity in phenotypic and allelic composition, with\n                      <jats:italic>HLA\u2010B<\/jats:italic>\n                      variants associated with distinct patterns of disease expression. Overall,\n                      <jats:italic>HLA\u2010B*35:02<\/jats:italic>\n                      was significantly enriched in children with IBD\u2010AA (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007) and in the overall occurrence of IBD (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005), whereas\n                      <jats:italic>HLA\u2010B*57:01<\/jats:italic>\n                      was significantly enriched in children with PsA (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These patterns suggest a key role for\n                      <jats:italic>HLA\u2010B<\/jats:italic>\n                      variants in disease pathogenesis, possibly driving diverse JSpA expression through distinct immunogenetic dysregulation. Our findings underscore the need to further elucidate the biologic connection between\n                      <jats:italic>HLA\u2010B<\/jats:italic>\n                      and JSpA, with potential insights that may inform clinical care and guide future investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90122","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:27:29Z","timestamp":1787045249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HLA<\/scp>\n                    \u2010B Associates With Distinct Disease Expression in Juvenile Spondyloarthritis: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3118-8303","authenticated-orcid":false,"given":"Dimitrios V.","family":"Bikas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-4871","authenticated-orcid":false,"given":"Timothy G.","family":"Brandon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Division of Rheumatology and Center for Pediatric Effectiveness, Roberts Center for Pediatric Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney N.","family":"Newby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-0443","authenticated-orcid":false,"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Division of Rheumatology and Center for Pediatric Effectiveness, Roberts Center for Pediatric Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine, University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"e_1_2_6_4_1","first-page":"390","article-title":"International League of Associations for Rheumatology. 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