{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:39:20Z","timestamp":1792665560201,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to identify and describe the clinical characteristics and outcomes in patients with pre\u2010existing idiopathic inflammatory myopathies (IIMs) in the Veterans Health Administration (VHA) treated with immune checkpoint inhibitors (ICIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All veterans receiving ICI infusions were identified. Patients with at least two\n                      <jats:italic>International Classification of Disease<\/jats:italic>\n                      codes for IIM before first ICI infusion underwent chart review to identify patients with confirmed IIM by American College of Rheumatology\/EULAR criteria. The demographics, cancer diagnoses, laboratory findings, clinical course, and mortality rates were reported. IIM cases were also reviewed to determine if patients developed IIM flare following ICI treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 29,539 veterans who received at least one ICI infusion in the VHA between June 6, 2011, and February 14, 2023. The eight patients with confirmed IIM before ICI treatment were mostly White men with an average age of 71.7 years at first ICI infusion. The IIM diagnoses were dermatomyositis in three patients, polymyositis in two, antisynthetase syndrome in two, and one rheumatoid arthritis (RA)\/myositis overlap. Cancer diagnoses were lung (two), melanoma (two), head and neck (two), kidney\/other urinary (one), and mesothelioma (one). Diagnosis of IIM was made on average 3.1 years before ICI treatment. One patient had an IIM flare after ICI. No IIM flares were identified in other patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings show that an IIM flare after ICI therapy can occur, but most patients did not develop a flare. These observations suggest ICIs can be considered as an option in patients with cancer with IIM with shared decision\u2010making and close monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90127","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:40:20Z","timestamp":1786344020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Immune Check Point Inhibitor Use in\n                    <scp>US<\/scp>\n                    Veterans With Pre\u2010Existing Idiopathic Inflammatory Myopathies: Case Series and Literature Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4704","authenticated-orcid":false,"given":"Denis","family":"Krutko","sequence":"first","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Rubino","sequence":"additional","affiliation":[{"name":"Rheumatology Division Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-0845","authenticated-orcid":false,"given":"Jessica A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rojas","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Medical Service VA Puget Sound Health Care System Seattle Division  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shardool","family":"Patel","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-9173","authenticated-orcid":false,"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawnie J.","family":"Braaten","sequence":"additional","affiliation":[{"name":"Medical Service VA Salt Lake City Health Care System  Salt Lake City Utah"},{"name":"Rheumatology Division, Department of Medicine University of Utah Health  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00854-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0160-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0237"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552231171881"},{"key":"e_1_2_6_8_1","unstructured":"Corporate Data Warehouse (CDW).US Department of Veterans Affairs. 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Last updated December 1 2020.https:\/\/www.data.va.gov\/dataset\/Veterans-Affairs-Central-Cancer-Registry-VACCR-\/jvmd-8fgj\/about_data"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011795"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14387"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.038"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13141"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41068"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2073"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.09.027"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr2.90127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:55:52Z","timestamp":1792662952000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.90127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/acr2.90127"],"URL":"https:\/\/doi.org\/10.1002\/acr2.90127","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e90127"}}