{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:59:54Z","timestamp":1790236794181,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early diffuse cutaneous systemic sclerosis (dcSSc) is associated with substantial disease\u2010specific mortality.\u00a0 Scleroderma\u2010specific autoantibodies (SSc\u2010Ab) may influence disease course, but their prognostic value in very early dcSSc remains unclear. We examined associations between autoantibody profiles and disease trajectories for clinical events in a prospective single\u2010center cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed prospectively collected data from a subset of patients enrolled in an early SSc registry between October 2012 and July 2021, including those with early dcSSc or individuals at risk for dcSSc less than two years of their first non\u2010Raynaud phenomenon (RP) symptom. Participants were classified as anti\u2010RNA polymerase III antibody positive (RNAP3+), anti\u2010topoisomerase I antibody positive (Scl70+), or triple\u2010negative (negative for RNAP3, Scl70, and anticentromere antibody [ACA]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 115 patients with available SSc\u2010Ab data (median follow\u2010up, 5.5 years [interquartile range 2.1\u20137.2]), 42 were RNAP3+, 29 Scl70+, 6 ACA+, and 38 triple\u2010negative. ACA+ patients were excluded from subgroup analyses because of the small sample size. Of the remaining 109 patients, 17 with prior clinical events at baseline were excluded from time\u2010to\u2010event analyses. Among the 92 included patients, 50 (54.3%) experienced one or more new clinical events during follow\u2010up, including 59.4% of RNAP3+, 57.1% of Scl70+, and 46.9% of triple\u2010negative patients. Among first new clinical events, RNAP3+ patients had higher frequencies of scleroderma renal crisis (6.3% vs 3.6% in Scl70+ and 0% in triple\u2010negative), malignancy (35.7% vs 24.1% and 15.8%, respectively), mortality (9.4% vs 3.6% and 0%, respectively), and forced vital capacity decline (15.6% vs 10.7% and 12.5%, respectively), whereas modified Rodnan skin score worsening was most frequent in triple\u2010negative patients (15.6% vs 10.7% in Scl70+ and 9.4% in RNAP3+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Scleroderma\u2010specific autoantibodies in early SSc were associated with distinct baseline clinical phenotypes and showed numerical differences in longitudinal clinical outcomes in this single\u2010center cohort.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr290142-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90142","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:07:01Z","timestamp":1789535221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scleroderma\u2010Specific Autoantibodies and Disease Trajectories in Early Systemic Sclerosis: Insights From a Single\u2010Center Prospective Registry"],"prefix":"10.1002","volume":"8","author":[{"given":"Marzieh","family":"Jamali","sequence":"first","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha","family":"Kaur","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"},{"name":"Division of Rheumatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carleigh","family":"Zahn","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"},{"name":"Division of Rheumatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Mulcaire\u2010Jones","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"},{"name":"Division of Rheumatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"},{"name":"Division of Rheumatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"Scleroderma Program University of Michigan  Ann Arbor MI USA"},{"name":"Division of Rheumatology, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2025.2490729"},{"key":"e_1_2_7_3_1","first-page":"1624","article-title":"Systemic sclerosis: advances and prospects","volume":"390","author":"The Lancet","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/23971983251334162"},{"key":"e_1_2_7_5_1","article-title":"Impact of systemic sclerosis\u2010associated interstitial lung disease, with and without pulmonary hypertension, on survival: a systematic review","volume":"17","author":"Rana SS","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0506-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00765-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2024.0129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02548-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.587773"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar628"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab735"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roab118"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.23"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00762.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.03.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.238"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12510"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103220"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/23971983251357991"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000971"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205226"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217455"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2020.102107"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000047876"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2026.106898"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160817"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08930-4"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr2.90142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.90142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:21:06Z","timestamp":1790234466000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.90142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/acr2.90142"],"URL":"https:\/\/doi.org\/10.1002\/acr2.90142","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e90142"}}