{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:35:43Z","timestamp":1793097343507,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate disease burden, treatment patterns, and impact of delayed diagnosis on patient outcomes in Sj\u00f6gren's disease (SjD) in a real\u2010world setting in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from the Adelphi Primary Sj\u00f6gren's Syndrome Disease Specific Programme, a US\u2010based cross\u2010sectional collaborative survey between rheumatologists and their next six consecutive consulting patients with SjD. Rheumatologists provided patients\u2019 demographic and clinical information using medical records and a patient\u2010completed questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rheumatologists (N = 84) provided data on 511 patients with SjD. Calculated Clinical EULAR Sj\u00f6gren's Syndrome Disease Activity Index (ClinESSDAI)\u2013proxy scores (ps) indicated that patients had mild (44.2%), moderate (30.9%), or severe (24.9%) disease. Among 297 patients, 33.7% had a EULAR Sj\u00f6gren's Syndrome Patient\u2010Reported Index (ESSPRI)\u2010ps of \u22655. Descriptive trends in patient\u2010reported EuroQoL 5\u2010Dimension 3\u2010Level (EQ\u20105D\u20103L) utility, EuroQoL Visual Analog Scale (EQ\u2010VAS), Functional Assessment of Chronic Illness Therapy\u2013Fatigue (FACIT\u2010F), and Work Productivity and Activity Impairment questionnaire scores suggested worsening impairment with increasing SjD severity. Mean (\u00b1SD) time to diagnosis was 2.3 (\u00b15.6) years. EQ\u20105D\u20103L utility (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.042), EQ\u2010VAS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026), FACIT\u2010F (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007) scores, and ESSPRI\u2010ps (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001) differed significantly by duration of diagnostic delay. The odds of ClinESSDAI\u2010ps and ESSPRI\u2010ps \u22655 at data collection were 2.3 and 2.1 times greater, respectively, in patients diagnosed &gt;12 versus &lt;3 months after symptom onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater ClinESSDAI severity, longer diagnostic delays, and inefficient patient referrals were associated with worsened symptom management and poorer outcomes. Patients with moderate\/severe disease who do not receive timely advanced treatment may experience greater disease burden, highlighting an unmet treatment need.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90143","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:35:13Z","timestamp":1790310913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient Journey, Disease Burden, Treatment Patterns, and the Impact of Delayed Diagnosis Among Patients With Sj\u00f6gren's Disease: A Real\u2010World\n                    <scp>US<\/scp>\n                    Survey"],"prefix":"10.1002","volume":"8","author":[{"given":"Anjana","family":"Lalla","sequence":"first","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antton","family":"Egana","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Milligan","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Massey","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Haughton","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23173"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"3","article-title":"One year in review 2020: pathogenesis of primary Sj\u00f6gren's syndrome","volume":"38","author":"Bombardieri M","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2017.0354"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"97","article-title":"Sj\u00f6gren Big Data Consortium. 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