{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:45:09Z","timestamp":1791949509689,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of cytokine\u2010directed therapies in VEXAS (vacuoles, E1 enzyme, X\u2010linked, autoinflammatory somatic) syndrome using previously proposed treatment response criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with genetically confirmed VEXAS syndrome who received targeted therapies with JAK inhibitors (JAKi), tumor necrosis factor \u03b1 inhibitors (TNF\u03b1i), or interleukin\u20101 (IL\u20101) or IL\u20106 inhibitors were identified. Clinical and biochemical data were recorded for patients at time of targeted therapy initiation, and at 3\u2010, 6\u2010, and 12\u2010month follow\u2010up time points. Treatment response was labeled as complete response (CR; normalization of C\u2010reactive protein [CRP], prednisone &lt;10 mg\/day, and resolution of disease activity), partial response (PR; &gt;50% improvement in CRP, &gt;50% prednisone dose reduction, improvement or resolution of disease features), treatment failure (TF; worsening CRP, increasing prednisone, worsening of disease features), or no response (not meeting criteria for CR, PR, or TF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 52 patients received an IL\u20101i, IL\u20106i, or JAKi therapy. At six\u2010month follow\u2010up, 3 of 19 IL\u20106i patients experienced CR, 4 of 19 experienced PR, and 7 of 19 experienced TF. 2 of 17 patients receiving JAKi experienced CR, 3 of 17 experienced PR, and 6 of 17 experienced TF. No patients receiving IL\u20101i or TNF\u03b1i experienced CR, and only 1 of 5 IL\u20101i patients experienced PR. Among those still receiving biologic therapy at 12 months, only 1 of 11 receiving IL\u20106i and 0 of 7 receiving JAKi experienced CR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u20106i and JAKi therapies demonstrated limited, unsustained efficacy for management of VEXAS syndrome. IL\u20101i and TNF\u03b1i therapies were not efficacious. Useful application of previously reported treatment response criteria was demonstrated, but future incorporation of hematologic parameters may be beneficial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.90153","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:12:54Z","timestamp":1790255574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Efficacy of Cytokine\u2010Directed Therapies in the Management of\n                    <scp>VEXAS<\/scp>\n                    Syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"Daniel","family":"Montes","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Langenfeld","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-7475","authenticated-orcid":false,"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota"},{"name":"Department of Internal Medicine, Division of Rheumatology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal M.","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Kalantari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Kusne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terra","family":"Lasho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek A.","family":"Mangaonkar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horatiu","family":"Olteanu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaaren K.","family":"Reichard","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-1534","authenticated-orcid":false,"given":"Megan M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Mayo Clinic  Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Viswanatha","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Warrington","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6755","authenticated-orcid":false,"given":"Matthew J.","family":"Koster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026834"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001905"},{"issue":"26","key":"e_1_2_6_4_1","first-page":"3591","article-title":"VEXAS syndrome","volume":"137","author":"Grayson 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