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Biosys."],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Wear\u2010debris\u2010induced osteolysis and subsequent aseptic loosening of the prosthesis are the main reasons for failed arthroplasty. Inhibition of wear\u2010debris\u2010induced osteoclastogenesis is thus a promising method to prolong the lifetime of prostheses. In this work, a mussel\u2010derived peptide, capped with an integrin\u2010targeting RGD tripeptide and a titanium (Ti)\u2010affinity tetrapeptide with catechol groups at each end is biomimetically designed. The RGD peptide can interfere with integrin \u03b1\n                    <jats:sub>v<\/jats:sub>\n                    \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    to affect the cytoskeletal organization and functions of osteoclasts and subsequently inhibit osteoclast hyperactivation and osteoclastogenesis in vitro and in vivo, while the catechol groups could easily adhere to the TiO\n                    <jats:sub>2<\/jats:sub>\n                    layer of the Ti implant via Ti\u2013catechol coordination. This design thus enables the stable immobilization of the RGD peptide on Ti implants to inhibit osteoclast formation and reduce osteolysis in vivo, even with the existence of Ti wear particles. Further study reveals that the suppression of osteoclastogenesis and osteoclast polarization on the peptide coating is regulated by blocking the PI3K\/AKT and NF\u2010\u03baB signal pathways. Considering the simplicity in the surface engineering, the highly biomimetic nature of the bioactive peptide, and efficient inhibition of wear\u2010debris\u2010caused osteolysis, this work thus presents a simple and efficient strategy to improve clinical outcome of prosthesis implantation in challenging conditions.\n                  <\/jats:p>","DOI":"10.1002\/adbi.201800253","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T14:37:01Z","timestamp":1541687821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficient Inhibition of Wear\u2010Debris\u2010Induced Osteolysis by Surface Biomimetic Engineering of Titanium Implant with a Mussel\u2010Derived Integrin\u2010Targeting Peptide"],"prefix":"10.1002","volume":"3","author":[{"given":"Xiaobin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Suzhou Municipal Hospital Affiliated to Nanjing Medical University Suzhou Jiangsu 215008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jining","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu 212001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu 212001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5187-796X","authenticated-orcid":false,"given":"Guoqing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu 212001 China"},{"name":"Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University Zhenjiang Jiangsu 212013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1545-8"},{"key":"e_1_2_7_2_1","first-page":"1","author":"Hall M. 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