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Biosys."],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The advancement of cell injections has created a need for accurate, efficient, and low\u2010invasive injections. However, the conventional approaches to reduce cell damage during penetration, mainly optimization of micropipette tips and vision\u2010based automatic injections, have almost reached the limit. Here, described are the design and implementation of a robotic\u2010aided rotatory microinjection system to reduce cell deformation and penetration force during the injection. The homocentric rotation technology integrates an ultraprecise manipulation system with multiple degrees of freedom, which tremendously diminishes the damage to the cell. Through systematic tests on zebrafish embryo microinjection, compared with traditional straightforward cell injection techniques, the rotary cell injection approach is able to reduce the penetration deformation and force of the specimen up to 30%. This work breaks the performance limit of current microinjection techniques, and paves a new way for the development of low\u2010invasive cell injection systems. It is envisioned that this rotary microrobot system can excavate enormous applications in the field of biomedicine, such as artificial fertilization and gene therapy.<\/jats:p>","DOI":"10.1002\/adbi.201800274","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:11:59Z","timestamp":1554117119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low\u2010Invasive Cell Injection based on Rotational Microrobot"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-3040","authenticated-orcid":false,"given":"Haojian","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"},{"name":"CityU Shen Zhen Research Institute  Shen Zhen 518057 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"},{"name":"CityU Shen Zhen Research Institute  Shen Zhen 518057 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1166\/asem.2016.1869"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700531"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01367"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700324"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700175"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700751"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700289"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2017.25"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"29.20. 21","DOI":"10.1002\/cpps.50","volume":"91","author":"Hansen D. 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