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This leads to successful cross\u2010linking as demonstrated by higher cross\u2010linking degree and similar tensile strength of genipin cross\u2010linked conduits compared to formaldehyde cross\u2010linked conduits. Genipin cross\u2010linking also preserves NGC macro and microstructure as observed through scanning electron microscopy and spectral analysis. Most importantly, in vitro cell studies show that genipin, unlike the formaldehyde cross\u2010linked conduits, supports the viability of Schwann cells. Moreover, genipin cross\u2010linked conduits direct macrophages away from a pro\u2010inflammatory and toward a pro\u2010repair state. Overall, genipin is demonstrated to be an effective, safe, biocompatible, and anti\u2010inflammatory alternative to formaldehyde for cross\u2010linking clinical grade NGCs.<\/jats:p>","DOI":"10.1002\/adbi.201900212","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T07:55:47Z","timestamp":1581062147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Use of Genipin as an Effective, Biocompatible, Anti\u2010Inflammatory Cross\u2010Linking Method for Nerve Guidance Conduits"],"prefix":"10.1002","volume":"4","author":[{"given":"Zuzana","family":"Ko\u010d\u00ed","sequence":"first","affiliation":[{"name":"Tissue Engineering Research Group (TERG) Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland  Dublin 2 D02YN77 Ireland"},{"name":"Trinity Centre for Biomedical Engineering (TCBE) Trinity College Dublin  Dublin D02PN40 Ireland"},{"name":"Advanced 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