{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:17:33Z","timestamp":1782940653512,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830001"],"award-info":[{"award-number":["31830001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv. Biosys."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colistin acts as a last\u2010resort antibiotic against lethal infections by carbapenem\u2010resistant <jats:italic>Enterobacterial<\/jats:italic> pathogens. <jats:italic>Enterobacteriaceae<\/jats:italic> carrying mobile colistin resistance (MCR) genes are rapidly emerging and threatening human health and food safety. Despite <jats:italic>mcr\u20101<\/jats:italic> being prevalent in <jats:italic>Escherichia coli<\/jats:italic>, its dissemination in <jats:italic>Salmonella<\/jats:italic> is not well characterized. Herein, two unusual serotypes of colistin\u2010resistant <jats:italic>Salmonella<\/jats:italic> isolates are reported first, namely serotype Ngor (ST5399) and Goldcoast (ST2529). Using whole genome sequencing, it is shown that <jats:italic>mcr\u20101<\/jats:italic> is located on the IncHI2\u2010like plasmid pTB501 (188,527 bp) of strain SSDFZ54 and the IncX4\u2010type plasmid pTB602 (33,303 bp) in strain SSDFZ69, respectively. Furthermore, the backbone, <jats:italic>tra<\/jats:italic>\u2010 and antimicrobial resistance genes relative variable regions in the <jats:italic>mcr\u20101<\/jats:italic>\u2010bearing IncHI2 plasmids are systematically characterized. Phylogenetic analysis shows that all IncHI2\u2010type plasmids from non\u2010Chinese regions are clustered together, suggesting a possible Chinese origin. Taken together, these findings extend the understanding of <jats:italic>Salmonella<\/jats:italic> as a vehicle of <jats:italic>mcr\u20101<\/jats:italic> carriage and distribution.<\/jats:p>","DOI":"10.1002\/adbi.201900219","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T14:15:54Z","timestamp":1581430554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Carriage of Distinct <i>mcr\u20101<\/i>\u2010Harboring Plasmids by Unusual Serotypes of <i>Salmonella<\/i>"],"prefix":"10.1002","volume":"4","author":[{"given":"Biao","family":"Tang","sequence":"first","affiliation":[{"name":"Institute of Quality and Standard for Agro\u2010Products &amp; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010Products Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Quality and Standard for Agro\u2010Products &amp; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010Products Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang 310021 China"},{"name":"College of Food Science and Engineering Northwest Agriculture and Forestry University  Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest Agriculture and Forestry University  Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology &amp; Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest Agriculture and Forestry University  Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachar H.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Stony Brook University  101 Nicolls Road Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jia","sequence":"additional","affiliation":[{"name":"Non\u2010Coding RNA and Drug Discovery Key Laboratory of Sichuan Province Chengdu Medical College  Chengdu Sichuan 610500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Quality and Standard for Agro\u2010Products &amp; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010Products Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-0175","authenticated-orcid":false,"given":"Youjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology &amp; Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310058 China"},{"name":"Non\u2010Coding RNA and Drug Discovery Key Laboratory of Sichuan Province Chengdu Medical College  Chengdu Sichuan 610500 China"},{"name":"College of Animal Sciences Zhejiang University  Hangzhou Zhejiang 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00463-6"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000924"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00201"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30527-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900034"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03205-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005957"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02317-17"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.06.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0278-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_2_8_13_1","first-page":"562","volume":"8","author":"Huang X.","year":"2017","journal-title":"Front. 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