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Intravenous injection of mesenchymal stem cells (MSCs) for endometrium regeneration has limited effectiveness as the retention rate of transplanted cells is low. Hydrogel\u2010based tissue\u2010engineered solutions, such as MSC\u2010seeded bioscaffolds, are reported to increase retention rates; however, a less invasive alternative is still desirable. 560\u2010\u00b5m homogeneous Matrigel microspheres are fabricated, loading them with about 1500 MSCs and injecting them into the injured endometria of rats\u2019 uteri. This minimally invasive procedure is proved to significantly increase endometrium thickness by over onefold after 21 d (<jats:italic>p<\/jats:italic>\u00a0&lt; 0.0001) and fertility rates from 25% to 75% in impaired and repaired uteri (<jats:italic>p<\/jats:italic>\u00a0&lt; 0.001), respectively. 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