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In this system, near\u2010infrared light irradiation triggers H<jats:sub>2<\/jats:sub>S release in coacervate model protocells, leading to modulation of the behavior of living cells. The functional coacervate model protocells are prepared by loading metal\u2010alloyed plasmonic nanoparticles and an H<jats:sub>2<\/jats:sub>S donor into the liquid coacervate microdroplets. Upon light irradiation, the H<jats:sub>2<\/jats:sub>S signal messenger is released through the photothermal effect of plasmonic nanoparticles and photothermal mediated pyrolysis of the H<jats:sub>2<\/jats:sub>S donor. The H<jats:sub>2<\/jats:sub>S signal is delivered to the mammalian cell community to trigger depletion of reactive oxygen species, reduce the activity of lactate dehydrogenase and improve cell viability. This study provides a new approach to the implementation of chemical signaling in artificial cell colonies and protocell\/living cell consortia. 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