{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:51:49Z","timestamp":1790509909588,"version":"4.1.0"},"reference-count":137,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930003"],"award-info":[{"award-number":["31930003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41976087"],"award-info":[{"award-number":["41976087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nitrite and nitric oxide (NO) are two active nitrogen oxides that display similar biochemical properties, especially when interacting with redox\u2010sensitive proteins (i.e., hemoproteins), an observation serving as the foundation of the notion that the antibacterial effect of nitrite is largely attributed to NO formation. However, a growing body of evidence suggests that they are largely treated as distinct molecules by bacterial cells. Although both nitrite and NO are formed and decomposed by enzymes participating in the transformation of these nitrogen species, NO can also be generated via amino acid metabolism by bacterial NO synthetase and scavenged by flavohemoglobin. NO seemingly interacts with all hemoproteins indiscriminately, whereas nitrite shows high specificity to heme\u2010copper oxidases. Consequently, the homeostasis of redox\u2010sensitive proteins may be responsible for the substantial difference in NO\u2010targets identified to date among different bacteria. In addition, most protective systems against NO damage have no significant role in alleviating inhibitory effects of nitrite. Furthermore, when functioning as signal molecules, nitrite and NO are perceived by completely different sensing systems, through which they are linked to different biological processes.<\/jats:p>","DOI":"10.1002\/adbi.202100773","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:10:29Z","timestamp":1627297829000},"source":"Crossref","is-referenced-by-count":23,"title":["Physiological Roles of Nitrite and Nitric Oxide in Bacteria: Similar Consequences from Distinct Cell Targets, Protection, and Sensing Systems"],"prefix":"10.1002","volume":"5","author":[{"given":"Kailun","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Microbiology and College of Life Sciences Zhejiang University  Hangzhou Zhejiang 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-6563","authenticated-orcid":false,"given":"Haichun","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and College of Life Sciences Zhejiang University  Hangzhou Zhejiang 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(75)90157-1"},{"key":"e_1_2_9_2_1","first-page":"2","volume-title":"Advances in Meat Research","author":"Gill C. O.","year":"1986"},{"key":"e_1_2_9_3_1","first-page":"196","volume":"42","author":"Pierson M. D.","year":"1998","journal-title":"Food Technol."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/239165b0"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2018.06.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0363com"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1109"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0201-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400518y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2018.9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2009.07.002"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2020.07.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0390207"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13129"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800261-2.00005-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062608-103436"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20563.1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic902073z"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic9022757"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.06.004"},{"key":"e_1_2_9_14_2","first-page":"e00559","volume":"84","author":"Meng Q.","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01353"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7235"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)37025-0"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06987.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2011.01576.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.03.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic902423v"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar800089j"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971481a"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.09.013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-008-9191-2"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2011.02425.x"},{"key":"e_1_2_9_21_3","doi-asserted-by":"publisher","DOI":"10.1021\/ar500459j"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.25071"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081423"},{"key":"e_1_2_9_22_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.03.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07691.x"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1033133100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0307289"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06163-11"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.09.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ01025A"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05964.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005299107"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6391"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605746200"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.09.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708019200"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110971"},{"key":"e_1_2_9_30_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2011.02385.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303282200"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710178200"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2317"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02975456"},{"key":"e_1_2_9_33_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201136200"},{"key":"e_1_2_9_33_4","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.24.7812-7815.1997"},{"key":"e_1_2_9_33_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.083"},{"key":"e_1_2_9_33_6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510062200"},{"key":"e_1_2_9_33_7","doi-asserted-by":"publisher","DOI":"10.1021\/bi801491e"},{"key":"e_1_2_9_33_8","doi-asserted-by":"publisher","DOI":"10.1021\/bi900385g"},{"key":"e_1_2_9_33_9","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1354"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387661-4.00006-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0619-x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.02.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.07.035"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610888104"},{"key":"e_1_2_9_36_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708845200"},{"key":"e_1_2_9_36_4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506562103"},{"key":"e_1_2_9_36_5","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02052-16"},{"key":"e_1_2_9_37_1","first-page":"e01255","volume":"84","author":"Meng Q.","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050241v"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00001-09"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2007.06.008"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/153623104773547499"},{"key":"e_1_2_9_41_1","first-page":"169","volume-title":"Antimicrobials in Food","author":"Tompkin R. B.","year":"2005"},{"key":"e_1_2_9_42_1","first-page":"109","volume":"52","author":"Woods L. F. J.","year":"1982","journal-title":"J. Appl. Microbiol."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/5870"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6308761"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02601735"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01567751"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12091"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2013.62"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.224"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.135"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0991-4"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00546-15"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00448-16"},{"key":"e_1_2_9_51_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.011"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24684"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07194.x"},{"key":"e_1_2_9_52_3","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4833"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.02109.x"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613308113"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10378"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2010.04.001"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605174200"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001295"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.12.3960-3968.2005"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05290.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003049"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(08)36008-X"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110470200"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.09.021"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605888200"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.9.2333-2343.2002"},{"key":"e_1_2_9_64_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404417200"},{"key":"e_1_2_9_64_4","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00074-13"},{"key":"e_1_2_9_64_5","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.21.5898-5902.2002"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13356"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200731200"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/014290-0"},{"key":"e_1_2_9_66_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2011.02520.x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00836-13"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610656200"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000629"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.06.016"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00604-09"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03316-13"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062629"},{"key":"e_1_2_9_73_2","first-page":"1154","volume":"7","author":"Jin M.","year":"2016","journal-title":"Front. Microbiol."},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-140-10-2531"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.1.221-230.2003"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.614164"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.7.2104-2111.2003"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051643"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00201-07"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2109"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00371-15"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.10.005"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00095"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fny029"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.08.008"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003571107"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405188101"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00360"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00706"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202100773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.202100773","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202100773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:51:20Z","timestamp":1759423880000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202100773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":137,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/adbi.202100773"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202100773","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"article-number":"2100773"}}