{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:25:58Z","timestamp":1787318758987,"version":"build-2736575974"},"reference-count":149,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In humans with type 2 diabetes, at least 70% of patients exhibit islet amyloid plaques formed by misfolding islet amyloid polypeptides (IAPP). The oligomeric conformation and accumulation of the IAPP plaques lead to a panoply of cytotoxic effects on the islet \u03b2\u2010cells. Currently, no marketed therapies for the prevention or elimination of these amyloid deposits exist, and therefore significant efforts are required to address this gap. To date, most of the experimental treatments are limited to only in vitro stages of testing. In general, the proposed therapeutics use various targeting strategies, such as binding to the N\u2010terminal region of islet amyloid polypeptide on residues 1\u201319 or the hydrophobic region of IAPP. Other strategies include targeting the peptide self\u2010assembly through \u03c0\u2010stacking. These methods are realized by using several different families of compounds, four of which are highlighted in this review: naturally occurring products, small molecules, organometallic compounds, and nanoparticles. Each of these categories holds immense potential to optimize and develop inhibitor(s) of pancreatic amyloidosis in the near future.<\/jats:p>","DOI":"10.1002\/adbi.202101301","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T21:28:55Z","timestamp":1659734935000},"source":"Crossref","is-referenced-by-count":10,"title":["Recent Advances in the Discovery of Therapeutics to Curtail Islet Amyloid Polypeptide Aggregation for Type 2 Diabetes Treatment"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-1028","authenticated-orcid":false,"given":"Alyssa A.","family":"Smith","sequence":"first","affiliation":[{"name":"Basic Medical Sciences College of Veterinary Medicine Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-1865","authenticated-orcid":false,"given":"Kendall B. E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences College of Veterinary Medicine Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Ambs","sequence":"additional","affiliation":[{"name":"Kalamazoo College  Kalamazoo MI 49006 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-8936","authenticated-orcid":false,"given":"Akella Prasanth","family":"Saraswati","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences College of Veterinary Medicine Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-9360","authenticated-orcid":false,"given":"Jessica S.","family":"Fortin","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences College of Veterinary Medicine Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2005.00318.x"},{"key":"e_1_2_9_2_1","first-page":"795","volume":"91","author":"Westermark P.","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.11.039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08240"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.12.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2015.01.291"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2021.183691"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25851"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.170"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.5.5.527"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(89)90008-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090532"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200602034"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1070824"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81467-X"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.02.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.11.016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400525m"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.022"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051195"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b01050"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3199"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2017.07.015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.07.031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2020.106532"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2018.410-422"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0202"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.06.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.8.1052"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(86)90031-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129809007298"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1672"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010116"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1464"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00284.2009"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00028"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809002a"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0037"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00160"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP04431J"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2046327"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21614"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09510"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00764C"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065579"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00015"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.02.010"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2023"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18807-8"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2017.09.004"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.100"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180820"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061314"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1517-2"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.10.013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470559277.ch110252"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.03.012"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700236R"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.04.012"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56500-0"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00123"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1mt00062d"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20168"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068207j"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc10860c"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590501.2015.1055161"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201100413"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2019.110807"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.08.012"},{"key":"e_1_2_9_72_1","first-page":"798","volume":"275","author":"Gonzalez P. K.","year":"1995","journal-title":"Shock"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.03.017"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.05.006"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-017-1484-x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00021H"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr33193h"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605151"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007824"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8041806"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CP05924K"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065579"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00051"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CP07501H"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00166"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00385"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0734"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.04.004"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100020w"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2009.042"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91311-2"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.11.083"},{"key":"e_1_2_9_93_1","volume":"12","author":"Thota R. N.","year":"2020","journal-title":"Nutrients"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b01009"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092677"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.06.029"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.11.004"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112197"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12261"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b05247"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.11.050"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.062"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01234"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070788"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2012.762761"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.12.013"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf201702h"},{"key":"e_1_2_9_108_1","volume":"25","author":"Meng Q.\u2010Y.","year":"2020","journal-title":"Molecules"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25851"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2012.02.001"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1735"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi2015162"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33076"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111837"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3115696"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja406831n"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2129"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079834"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00039"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00170"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104023"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2020.100303"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11078"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-020-01398-6"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874091X01206010066"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b08652"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5416-4_8"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19463"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.01.047"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200800762"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2016.1254538"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24216"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050111"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.02.042"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.05.001"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB02910A"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060964"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24080"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200705372"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0204"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi800043d"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi702518m"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3220859"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.02.021"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.034"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15112F"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-019-01637-6"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00891"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01301"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202101301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.202101301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202101301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:42:48Z","timestamp":1759426968000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202101301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":149,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/adbi.202101301"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202101301","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"article-number":"2101301"}}