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Initially, two ceRNA networks with 19 and 3 differentially expressed (DE) hub lncRNAs are reconstructed in SARS\u2010CoV\u20102 infected Frontal Cortex (FC) and Choroid Plexus (CP), respectively. Functional and pathway enrichment analyses of downstream mRNAs of deregulated ceRNA axes demonstrate impairment of neurological processes. Mapping of hub lncRNA\u2010mRNA pairs from bulk RNA\u2010seq with snRNA\u2010seq data has indicated that NORAD, NEAT1, and STXBP5\u2010AS1 are downregulated across 4, 4, and 2 FC cell types, respectively. At the same time, MIRLET7BHG and MALAT1 are upregulated in excitatory neurons of FC and neurons of CP, respectively. Here, it is hypothesized that downregulation of NORAD, NEAT1, and STXBP5\u2010AS1, and upregulation of MIRLET7BHG and MALAT1 might deregulate respectively 51, 6, and 37, and 31 and 19 mRNAs in cell types of FC and CP. Afterward, 13 therapeutic miRNAs are traced that might safeguard against deregulated lncRNA\u2010mRNA pairs of NORAD, NEAT1, and MIRLET7BHG in FC. This study helps to explain the plausible mechanism of post\u2010COVID neurological manifestation and also to devise therapeutics against it.<\/jats:p>","DOI":"10.1002\/adbi.202101310","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T03:00:19Z","timestamp":1654311619000},"source":"Crossref","is-referenced-by-count":11,"title":["Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS\u2010CoV\u20102 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single\u2010Cell Transcriptomic Analyses"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-1916","authenticated-orcid":false,"given":"Deepyaman","family":"Das","sequence":"first","affiliation":[{"name":"Department of Microbiology Raiganj University  Raiganj Uttar Dinajpur West Bengal 733134 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-508X","authenticated-orcid":false,"given":"Soumita","family":"Podder","sequence":"additional","affiliation":[{"name":"Department of Microbiology Raiganj University  Raiganj Uttar Dinajpur West Bengal 733134 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061088"},{"key":"e_1_2_9_2_1","first-page":"1135","volume":"7","author":"Liu Y.","year":"2021","journal-title":"Front. 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