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Here, the DCMs model by human\u2010induced pluripotent stem cells\u2010derived cardiomyocytes is developed. Two subtypes of GLP\u20101, GLP\u20101<jats:sub>7\u201336<\/jats:sub> and GLP\u20101<jats:sub>9\u201036<\/jats:sub>, are evaluated for their efficacy on the DCMs model. Diabetogenic condition is sufficient to induce most characteristics of diabetic cardiomyopathy in vitro, such as cardiac hypertrophy, lipid accumulation, impaired calcium transients, and abnormal electrophysiological properties. GLP\u20101<jats:sub>7\u221236<\/jats:sub> and GLP\u20101<jats:sub>9\u201336<\/jats:sub> can restore cardiomyocyte hypertrophic phenotype, impaired calcium transient frequency, abnormal action potential amplitude, depolarization, and repolarization velocity. Interestingly, RNA\u2010seq reveals different pathways altered by GLP\u20101<jats:sub>7\u201336<\/jats:sub> and GLP\u20101<jats:sub>9\u201336<\/jats:sub>, respectively. Differentially expressed gene analysis reveals that possible targets of GLP\u20101<jats:sub>7\u201336<\/jats:sub> involve the regulation of mitotic nuclear division and extracellular matrix\u2013receptor interaction, while possible targets of GLP\u20101<jats:sub>9\u201336<\/jats:sub> involve kinetochore assembly, and the complement and coagulation cascades. This study demonstrates the therapeutic effects of GLP\u20101 on human DCMs and provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, shedding light on discovering better targets for novel therapeutic interventions.<\/jats:p>","DOI":"10.1002\/adbi.202200130","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:00:36Z","timestamp":1668405636000},"source":"Crossref","is-referenced-by-count":3,"title":["Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Rescue Diabetic Cardiac Dysfuntions in Human iPSC\u2010Derived Cardiomyocytes"],"prefix":"10.1002","volume":"7","author":[{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sir Run Run Hospital Nanjing Medical University  109 Longmian Avenue Nanjing 211166 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of 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