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The IBD\u2010mouse model is established by replacing normal water intake with 2.5% dextran sulfate sodium salt (DSS) aqueous solution, and 50\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    of AKBA treatment is administered. The experimental mice are randomly divided into four groups, including control, AKBA , DSS, and DSS + AKBA groups. AKBA therapy conspicuously ameliorates the adverse symptoms caused by DSS in mice and inhibits the reduction of colon length and the rise of disease activity index score. Hematoxylin\u2013eosin staining results suggest that AKBA strikingly improves the pathological conditions of the colon and small intestine tissues in IBD mice. AKBA prominently inhibits the DSS\u2010induced increase of proinflammatory factor contents and the upregulation of the c\u2010Jun N\u2010terminal kinase (JNK)\u2013p38\/mitogen\u2010activated protein kinase (MAPK) and Nuclear factor kappa B (NF\u2010\u03baB) pathways\u2019 protein levels in the colon tissues of IBD mice. AKBA alleviates DSS\u2010induced colonic inflammatory injury in IBD mice by repressing the activation of the JNK\u2013p38\/MAPK and NF\u2010\u03baB pathways.\n                  <\/jats:p>","DOI":"10.1002\/adbi.202200247","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:15:35Z","timestamp":1674173735000},"source":"Crossref","is-referenced-by-count":8,"title":["Acetyl\u201011\u2010keto\u2010\u03b2\u2010boswellic Acid Confers Protection in DSS\u2010Induced Colitis via the JNK\u2013p38 MAPK and NF\u2010\u03baB Signaling Pathways"],"prefix":"10.1002","volume":"7","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of TCM The Affiliated Xuzhou Central Hospital of Nanjing University of Chinese Medicine  Xuzhou City Jiangsu Province 221000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-6374","authenticated-orcid":false,"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of TCM Workers Hospital of China Coal No. 5 Construction Company  105 Huaihai West Road Xuzhou City Jiangsu Province 221000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2019.08.001"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000740"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i48.8242"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1574569"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2020-0095"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002306"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab065"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00835-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.892790"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6244757","volume":"2022","author":"Zhang F.","year":"2022","journal-title":"Oxid. 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