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This review presents a comprehensive overview of the therapeutic effects of ART\u2010based drugs, beyond their antimalarial effects. This review also summarizes the information on their repurposing in other pathologies, with the hope that it will guide the future optimization of the use of ART\u2010based drugs and of the treatment strategies for the listed diseases. By reviewing related literature, ART extraction and structure as well as the synthesis and structure of its derivatives are presented. Subsequently, the traditional roles of ART and its derivatives against malaria are reviewed, including antimalarial mechanism and occurrence of antimalarial resistance. Finally, the potential of ART and its derivatives to be repurposed for the treatment of other diseases are summarized. The great repurposing potential of ART and its derivatives may be useful for the control of emerging diseases with corresponding pathologies, and future research should be directed toward the synthesis of more effective derivatives or better combinations.<\/jats:p>","DOI":"10.1002\/adbi.202300086","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T09:34:52Z","timestamp":1683970492000},"source":"Crossref","is-referenced-by-count":17,"title":["Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review"],"prefix":"10.1002","volume":"7","author":[{"given":"Lin","family":"Guan","sequence":"first","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Humanwell Pharmaceutical Co. Ltd.  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