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Pathologically, Sjogren's syndrome are characterized by lymphocyte infiltration into the exocrine glands and epithelial cell destruction caused by autoantibodies Ro\/SSA and La\/SSB. At present, the exact pathogenesis of Sjogren's syndrome is unclear. Evidence suggests epithelial cell death and the subsequent dysfunction of salivary glands as the main causes of xerostomia. This review summarizes the modes of salivary gland epithelial cell death and their role in Sjogren's syndrome progression. The molecular mechanisms involved in salivary gland epithelial cell death during Sjogren's syndrome as potential leads to treating the disease are\u00a0also discussed.<\/jats:p>","DOI":"10.1002\/adbi.202300173","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T04:14:42Z","timestamp":1688616882000},"source":"Crossref","is-referenced-by-count":16,"title":["Modes and Mechanisms of Salivary Gland Epithelial Cell Death in Sjogren's Syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"Jiannan","family":"Zhou","sequence":"first","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak Lal","family":"Pathak","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Cao","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobumoto","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Chemical Biology Research Group RIKEN Center for Sustainable Resource Science  Wako Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Huo","sequence":"additional","affiliation":[{"name":"Experimental Animal Center Guangzhou Medical University  Guangzhou Guangdong 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-1362","authenticated-orcid":false,"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical University  Guangzhou Guangdong 510182 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205375"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3821"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05017-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.06.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23472-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113229"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.01.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.05.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102364"},{"key":"e_1_2_6_10_1","first-page":"354","volume":"114","author":"Stefanski A. 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