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Even cartilage tissue engineering still faces many problems such as complex composition and poor integration of scaffolds and host tissues. In this study, chondroitin sulfate, one of the main components of extracellular matrix (ECM), is chosen as the main natural component of the material, which can protect cartilage in a variety of ways. Moreover, the results show that the addition of chondroitin sulfate improves the mechanical properties of gelatin methacrylate (GelMA) hydrogel, making it able to effectively bear mechanical loads in vivo. Further, chondroitin sulfate is modified to obtain the oxidized chondroitin sulfate (OCS) containing aldehyde groups via sodium periodate. This special group improves the interface integration and adhesion ability of the hydrogel to host cartilage tissue through schiff base reactions. In summary, GelMA\/OCS hydrogel is a promising candidate for cartilage regeneration with good biocompatibility, mechanical properties, tissue integration ability, and excellent cartilage repair ability.<\/jats:p>","DOI":"10.1002\/adbi.202300249","type":"journal-article","created":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T22:46:24Z","timestamp":1693176384000},"source":"Crossref","is-referenced-by-count":15,"title":["Chondroitin Sulfate Improves Mechanical Properties of Gelatin Hydrogel for Cartilage Regeneration in Rats"],"prefix":"10.1002","volume":"7","author":[{"given":"Tao","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrang","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science&amp;Technology  Nanjing 210094 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science&amp;Technology  Nanjing 210094 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangrong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfa","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3577-0797","authenticated-orcid":false,"given":"Binghua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 32200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201304304"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39465"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.11.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13329"},{"key":"e_1_2_9_6_1","first-page":"2731","volume":"27","author":"Becher C.","year":"2019","journal-title":"Arthroscopy : Offic. 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