{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:34:45Z","timestamp":1788305685552,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172381"],"award-info":[{"award-number":["82172381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302760"],"award-info":[{"award-number":["82302760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuromodulation\u2010related intervertebral disc degeneration (IVDD) is a novel IVDD pattern and are proposed recently. However, the mechanistic basis of neuromodulation and intervertebral disc (IVD) homeostasis remains unclear. Here, this study aimed to investigate the expression of postganglionic sympathetic nerve fiber\u2010derived vasoactive intestinal peptide (VIP) system in human IVD tissue, and to assess the role of VIP\u2010related neuromodulation in IVDD. Patient samples and in vitro cell experiments showed that the expression of receptors for VIP is negatively correlated with the severity of IVDD, and the administration of exogenous VIP can ameliorate interleukin 1\u03b2\u2010induced nucleus pulposus (NP) cell apoptosis and inflammation. Further mRNA\u2010seq analysis revealed that fibroblast growth factor 18\u2010 (FGF18)\u2010mediated activation of V\u2010akt murine thymoma viral oncogene homolog signaling pathway is involved in the protective effects of VIP on inflammation\u2010induced NP cell degeneration. Further analysis identified VIP via its receptor vasoactive intestinal peptide receptor 2 can directly result in decreased expression of miR\u201015a\u20105p, which targeted FGF18. Finally, in vivo mice lumbar IVDD model confirmed that focally exogenous administration of VIP can effectively ameliorated the progression of IVDD, as shown by the radiological and histological analysis. In conclusion, these results indicated that sympathetic neurotransmitter, VIP, delayed IVDD via FGF18\/FGFR2\u2010mediated activation of V\u2010akt murine thymoma viral oncogene homolog signaling pathway, which will broaden the horizon concerning how the neuromodulation correlates with IVDD and shed new light on novel therapeutical alternatives to IVDD.<\/jats:p>","DOI":"10.1002\/adbi.202300250","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T07:08:35Z","timestamp":1701673715000},"source":"Crossref","is-referenced-by-count":7,"title":["Sympathetic Neurotransmitter, VIP, Delays Intervertebral Disc Degeneration via FGF18\/FGFR2\u2010Mediated Activation of Akt Signaling Pathway"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-8383","authenticated-orcid":false,"given":"Kaiqiang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  No.415 Fengyang Road Shanghai 200003 China"},{"name":"Department of Orthopedics Naval Medical Center of PLA Navy Medical University  No.338 Western HuaiHai Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Naval Medical Center of PLA Navy Medical University  No.338 Western HuaiHai Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00733-9"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.160"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0337-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101733"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2958584"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1911914"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0280-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.01.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4479"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0469-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.524090"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041579"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.687024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00493.2012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.638128"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.11.006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100978"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45359"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.12.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/87887"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0410-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00713-z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.04.012"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110660"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.03.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112170"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13057"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","unstructured":"T.Yurube M.Ito Y.Kakiuchi R.Kuroda K.Kakutani J. O. R.Spine 2020 3 e1082.","DOI":"10.1002\/jsp2.1082"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39739"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24042"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518764260"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0514"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111920"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3225439"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00753-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9067611","volume":"2022","author":"Zheng Y.","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300250"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202300250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:49:44Z","timestamp":1759420184000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202300250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/adbi.202300250"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202300250","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"article-number":"2300250"}}