{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:09:51Z","timestamp":1791670191296,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type A aortic dissection (AD) is a catastrophic cardiovascular disease. Hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) and autophagy are reported to be upregulated in the AD specimens. However, the interaction between HIF\u20101\u03b1 and autophagy in the pathogenesis of AD remains to be explored. HIF\u20101\u03b1 and LC3 levels are evaluated in 10 AD and 10 normal aortic specimens. MDC staining, autophagic vacuoles, and autophagic flux are detected in human aortic smooth muscle cells (HASMCs) under hypoxia treatment. CCK\u20108, transwell, and wound healing assay are used to identify proliferation and migration under hypoxia treatment. Furthermore, 3\u2010MA is used to inhibit autophagy in hypoxia\u2010treated HASMCs. This study reveals that AD tissues highly express HIF\u20101\u03b1 and the LC3. Autophagy is induced under hypoxia in a time\u2010dependent manner, and autophagy is positively related to HIF\u20101\u03b1 in HASMCs. Moreover, the proliferation and migration of HASMCs are enhanced by hypoxia, whereas the knockdown of HIF\u20101\u03b1 attenuates this effect. Additionally, inhibiting autophagy with 3\u2010MA ameliorates hypoxia\u2010induced proliferation and migration of HASMCs. In summary, the above results indicate that HIF\u20101\u03b1 facilitates HASMC proliferation and migration by upregulating autophagy in a hypoxic microenvironment. Thus, inhibition of autophagy may be a novel therapeutic target for the prevention and treatment of AD.<\/jats:p>","DOI":"10.1002\/adbi.202300292","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:24:58Z","timestamp":1696296298000},"source":"Crossref","is-referenced-by-count":12,"title":["HIF\u20101\u03b1 Contributes to Hypoxia\u2010induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection"],"prefix":"10.1002","volume":"8","author":[{"given":"Ben","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Zhongshan Hospital Fudan University  Shanghai 200032 P.R. 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