{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:52:16Z","timestamp":1790700736564,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["RRF\u20102.3.1\u201021\u20102022\u201000004"],"award-info":[{"award-number":["RRF\u20102.3.1\u201021\u20102022\u201000004"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aging has strong genetic components and the list of genes that may regulate the aging process is collected in the GenAge database. There may be characteristic patterns in the amino acid sequences of aging\u2010related proteins that distinguish them from other proteins and this information will lead to a better understanding of the aging process. To test this hypothesis, human protein sequences are extracted from the UniProt database and the relative frequency of every amino acid residue in aging\u2010related proteins and the remaining proteins is calculated. The main observation is that the mean relative frequency of aspartic acid (D) is consistently higher, while the mean relative frequencies of tryptophan (W) and leucine (L) are consistently lower in aging\u2010related proteins compared to the non\u2010aging\u2010related proteins for the human and four examined model organisms. It is also observed that the mean relative frequency of aspartic acid is higher, while the mean relative frequency of tryptophan is lower in pro\u2010longevity proteins compared to anti\u2010longevity proteins in model organisms. Finally, it is found that aging\u2010related proteins tend to be longer than non\u2010aging\u2010related proteins. It is hoped that this analysis initiates further computational and experimental research to explore the underlying mechanisms of these findings.<\/jats:p>","DOI":"10.1002\/adbi.202300436","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T01:13:20Z","timestamp":1698282800000},"source":"Crossref","is-referenced-by-count":1,"title":["Unique Patterns in Amino Acid Sequences of Aging\u2010Related Proteins"],"prefix":"10.1002","volume":"8","author":[{"given":"Eszter Zita","family":"Szatm\u00e1ri","sequence":"first","affiliation":[{"name":"Institute for Computer Science and Control (SZTAKI) Hungarian Research Network (HUN\u2010REN)  Budapest 1111 Hungary"},{"name":"Department of Applied Analysis and Computational Mathematics E\u00f6tv\u00f6s Lor\u00e1nd University (ELTE)  P\u00e1zm\u00e1ny P\u00e9ter s\u00e9t\u00e1ny 1\/C Budapest 1117 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Csord\u00e1s","sequence":"additional","affiliation":[{"name":"AgeCurve Limited  Cambridge CB21SD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-246X","authenticated-orcid":false,"given":"Csaba","family":"Kerepesi","sequence":"additional","affiliation":[{"name":"Institute for Computer Science and Control (SZTAKI) Hungarian Research Network (HUN\u2010REN)  Budapest 1111 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1042"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/366461a0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01098"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023356005749"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08980"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.07.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22240-w"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204420"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tma.2019.09.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.02.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00443.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212218"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.559998"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.10.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00317-6"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202300436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:51:40Z","timestamp":1759420300000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202300436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,25]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/adbi.202300436"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202300436","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,25]]},"article-number":"2300436"}}