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Since there is no therapy for CADASIL the authors investigate whether the\u00a0multi\u2010modal neuropeptide drug Cerebrolysin may improve outcome in a murine CADASIL model. Twelve\u2010month\u2010old <jats:italic>NOTCH3<\/jats:italic><jats:sup>R169C<\/jats:sup> mutant mice (n=176) are treated for nine weeks with Cerebrolysin or Vehicle and histopathological and functional outcomes are evaluated within the subsequent ten months. Cerebrolysin treatment improves spatial memory and overall health, reduces epigenetic aging, and prolongs lifespan, however, CADASIL\u2010specific white matter vacuolization is not affected. On the molecular level Cerebrolysin treatment increases expression of Calcitonin Gene\u2010Related Peptide (CGRP) and Silent Information Regulator Two (Sir2)\u2010like protein 6 (SIRT6), decreases\u00a0expression of Insulin\u2010like Growth Factor 1 (IGF\u20101), and normalizes the expression of neurovascular laminin. In summary, Cerebrolysin fosters\u00a0longevity and healthy aging without specifically affecting CADASIL pathology. Hence, Cerebrolysin may serve a therapeutic option for CADASIL and other disorders characterized by accelerated aging.<\/jats:p>","DOI":"10.1002\/adbi.202300439","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T02:05:45Z","timestamp":1702001145000},"source":"Crossref","is-referenced-by-count":4,"title":["Treatment with Cerebrolysin Prolongs Lifespan in a Mouse Model of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-655X","authenticated-orcid":false,"given":"Birgit","family":"Kastberger","sequence":"first","affiliation":[{"name":"Ever Pharma  Oberburgau 3 Unterach am Attersee 4866 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Winter","sequence":"additional","affiliation":[{"name":"Ever Pharma  Oberburgau 3 Unterach am Attersee 4866 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemma","family":"Brandst\u00e4tter","sequence":"additional","affiliation":[{"name":"Ever Pharma  Oberburgau 3 Unterach am Attersee 4866 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Biller","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich  81377 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology RWTH Aachen University Medical School  52074 Aachen Germany"},{"name":"Helmholtz Institute for Biomedical Engineering RWTH Aachen University  52074 Aachen Germany"},{"name":"Cygenia GmbH  52078 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Plesnila","sequence":"additional","affiliation":[{"name":"Cluster of Systems Neurology (Synergy)  81377 Munich Germany"},{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich  81377 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.074583"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh282"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1192\/apt.bp.107.004655"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/383707a0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1853-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"K. 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