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However, the mechanisms of liver injury induced by environmental pollutants are largely unclear. Here, using tetrabromobisphenol A (TBBPA), a widely used brominated flame retardant, as an example, environmental toxin\u2010induced liver toxicity in mice is characterized via single\u2010cell sequencing technology. Heterogeneous gene expression profiles after exposure to TBBPA in major cell types of the liver are demonstrated. In hepatocytes, pathway analysis of differentially expressed genes reveals the enhanced interferon response and diminished metabolic processes. The disrupted endothelial functions in TBBPA\u2010treated cells are then shown. Moreover, the activation of M2\u2010polarization in Kupffer cells, as well as activated effector T and B cells are unveiled in TBBPA\u2010treated cells. Finally, ligand\u2010receptor pair analysis shows that TBBPA disrupts cell\u2010cell communication and induces an inflammatory microenvironment. Overall, the results reveal that TBBPA\u2010induced dysfunction of hepatocytes and endothelial cells may then activate and recruit other immune cells such as Kuffer cells, and T\/NK cells into the liver, further increasing inflammatory response and liver injury. Thus, the results provide novel insight into undesiring environmental pollutant\u2010induced liver injury.<\/jats:p>","DOI":"10.1002\/adbi.202300477","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:39:17Z","timestamp":1698021557000},"source":"Crossref","is-referenced-by-count":2,"title":["Insight into Tetrabromobisphenol A\u2010Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing"],"prefix":"10.1002","volume":"8","author":[{"given":"Yunmeng","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Nephrology Shenzhen Key Laboratory of Kidney Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen 518020 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Key Laboratory of Kidney Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen 518020 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Key Laboratory of Kidney Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen 518020 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Affiliated Hospital of Southwest Medical University  25 Taiping Street Luzhou 646000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Iyaswamy","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University  Kowloon Tong Hong Kong 000000 P. R. China"},{"name":"Department of Biochemistry Karpagam Academy of Higher Education  Coimbatore 641021 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Key Laboratory of Kidney Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen 518020 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Key Laboratory of Kidney Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen 518020 P. R. China"},{"name":"Department of Oncology The Affiliated Hospital of Southwest Medical University  25 Taiping Street Luzhou 646000 P. R. China"},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing 100700 P. R. 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