{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:47:50Z","timestamp":1759452470437,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201442"],"award-info":[{"award-number":["81201442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The liver is the major ketogenic organ of the body, and ketones are reported to possess favorable neuroprotective effects. This study aims to elucidate whether ketone bodies generated from the liver play a critical role in bridging the liver and spinal cord. Mice model with a contusive spinal cord injury (SCI) surgery is established, and SCI induces significant histological changes in mice liver. mRNA\u2010seq of liver tissue shows the temporal changes of ketone bodies\u2010related genes, \u03b2\u2010hydroxybutyrate dehydrogenase (BDH1) and solute carrier family 16 (monocarboxylic acid transporters), member 6 (SLC16A6). Then, an activated ketogenesis model is created with adult C57BL\/6 mice receiving the tail intravenous injection of GPAAV8\u2010TBG\u2010Mouse\u2010Hmgcs2\u2010CMV\u2010 mCherry \u2010WPRE (HMGCS2<jats:sup>liver<\/jats:sup>) and mice receiving equal AAV8\u2010Null being the control group (Vector<jats:sup>liver<\/jats:sup>). Then, the mice undergo either a contusive SCI or sham surgery. The results show that overexpression of HMG\u2010CoA synthase (Hmgcs2) in mice liver dramatically alleviates SCI\u2010mediated pathological changes and promotes ketogenesis in the liver. Amazingly, liver\u2010derived ketogenesis evidently alleviates neuron apoptosis and inflammatory microglia activation and improves the recovery of motor function of SCI mice. In conclusion, a liver\u2010spinal cord axis can be bridged via ketone bodies, and enhancing the production of the ketone body within the liver has neuroprotective effects on traumatic SCI.<\/jats:p>","DOI":"10.1002\/adbi.202300481","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T09:08:25Z","timestamp":1700644105000},"source":"Crossref","is-referenced-by-count":3,"title":["Liver\u2010Derived Ketogenesis via Overexpressing HMGCS2 Promotes the Recovery of Spinal Cord Injury"],"prefix":"10.1002","volume":"8","author":[{"given":"Xiaofei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of spine surgery, Changzheng Hospital Naval Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of spine surgery, Changzheng Hospital Naval Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-8383","authenticated-orcid":false,"given":"Kaiqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of spine surgery, Changzheng Hospital Naval Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fudong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of spine surgery, Changzheng Hospital Naval Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongping","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Zechong Biotechnology Co., Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Changhai Hospital Naval Medical University  No. 168 Changhai Road Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanqi","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of spine surgery, Changzheng Hospital Naval Medical University  No.415 Fengyang Road Shanghai 200003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Surgery, Changhai Hospital Naval Medical University  No. 168 Changhai Road Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07603-1"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-017-07550-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.670646"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47278-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200609000-00009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078765"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03156-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2020.1844829"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113725"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-S4-14"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122093"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.119.018762"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.08.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-6-31"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-29"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13788"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41394-018-0121-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-200410"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.825043"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9600-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.01.011"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35525-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.07.009"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9067611","volume":"2022","author":"Zheng Y.","year":"2022","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4184-05.2006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.629968"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202300481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:51:50Z","timestamp":1759420310000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202300481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/adbi.202300481"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202300481","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"type":"print","value":"2701-0198"},{"type":"electronic","value":"2701-0198"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"article-number":"2300481"}}