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Mineralocorticoid receptor (MR) blockade using Finerenone is a recently approved therapeutic approach to slow down the progression of DKD in patients with type 2 diabetes in addition to other therapies such as angiotensin\u2010II converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), sodium\u2010glucose co\u2010transporter 2 (SGLT2) inhibitors, and glucagon\u2010like peptide 1 (GLP\u20101) analogs. This review elaborates on the pathophysiologic pathways activated by aldosterone (the human mineralocorticoid) in DKD, the pharmacology of three different generations of mineralocorticoid receptor antagonists (MRAs), specifically, spironolactone, eplerenone, and finerenone, and the mechanisms by which these MRAs elicit their protective effects on the kidney under diabetic settings.<\/jats:p>","DOI":"10.1002\/adbi.202300496","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T22:59:56Z","timestamp":1702076396000},"source":"Crossref","is-referenced-by-count":5,"title":["Renoprotective Effects of Mineralocorticoid Receptor Antagonists Against Diabetic Kidney Disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Sarah","family":"Bayne","sequence":"first","affiliation":[{"name":"Drake University College of Pharmacy and Health Sciences  Des Moines IA 50311 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"LeFevre","sequence":"additional","affiliation":[{"name":"Drake University College of Pharmacy and Health Sciences  Des Moines IA 50311 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Olstinske","sequence":"additional","affiliation":[{"name":"Drake University College of Pharmacy and Health Sciences  Des Moines IA 50311 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenithya","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Reagents and Assay Development R&amp;D BD Biosciences  San Jose CA 95131 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-7705","authenticated-orcid":false,"given":"Shankar","family":"Munusamy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences Drake University College of Pharmacy and Health Sciences  Des Moines IA 50311 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i6505"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310799"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14007"},{"key":"e_1_2_9_5_1","unstructured":"I. 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