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The objective of this study is to investigate whether erythropoietin hepatocellular receptor B2 (EPHB2) can regulate myocardial injury after MI and explore its regulatory pathways. EPHB2 is significantly overexpressed in the heart tissues of MI mice. The downregulation of EPHB2 alleviates the cardiac function damage after MI. Knockdown EPHB2 alleviates MI\u2010induced myocardial tissue inflammation and apoptosis, and myocardial fibrosis in mice. EPHB2 knockdown significantly inhibits the activation of mitogen activated kinase\u2010like protein (MAPK) pathway in MI mice. Moreover, EPHB2 overexpression significantly promotes the phosphorylation of MAPK pathway\u2010related protein, which can be reversed by MAPK\u2010IN\u20101 (an MAPK inhibitor) treatment. In conclusion, silencing EPHB2 can mitigate MI\u2010induced myocardial injury by inhibiting MAPK signaling in mice, suggesting that targeting EPHB2 can be a promising therapeutic target for MI\u2010induced myocardial injury.<\/jats:p>","DOI":"10.1002\/adbi.202300517","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T22:05:55Z","timestamp":1719957955000},"source":"Crossref","is-referenced-by-count":8,"title":["EPHB2 Knockdown Mitigated Myocardial Infarction by Inhibiting MAPK Signaling"],"prefix":"10.1002","volume":"8","author":[{"given":"Xiaoyan","family":"Jiang","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Yantai Fushan People's Hospital  Yantai Shandong 265500 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Yantai Fushan People's Hospital  Yantai Shandong 265500 P. R. 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