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However, effective drugs to manage skeletal muscle atrophy and fibrosis remain elusive. This study isolated and characterized exosomes derived from skeletal muscle satellite cells (MuSC\u2010Exo). The study investigated their effects on denervated skeletal muscle atrophy and fibrosis in Sprague Dawley (SD) rats via intramuscular injection. MuSC\u2010Exo demonstrated the potential to alleviate skeletal muscle atrophy and fibrosis. The underlying mechanism using single\u2010cell RNA sequencing data and functional analysis are analyzed. Mechanistic studies reveal close associations between fibroblasts and myoblasts, with the transforming growth factor \u03b21 (TGF\u2010\u03b21)\u2010Smad3\u2010Pax7 axis governing fibroblast activation in atrophic skeletal muscle. MuSC\u2010Exo intervention inhibited the TGF\u2010\u03b21\/Smad3 pathway and improved muscle atrophy and fibrosis. In conclusion, MuSC\u2010Exo\u2010based therapy may represent a novel strategy to alleviate skeletal muscle atrophy and reduce excessive fibrotic tissue by targeting Pax7 through the TGF\u2010\u03b21\/Smad3 pathway.<\/jats:p>","DOI":"10.1002\/adbi.202300558","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T06:10:12Z","timestamp":1707372612000},"source":"Crossref","is-referenced-by-count":8,"title":["Satellite Cell\u2010Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis"],"prefix":"10.1002","volume":"8","author":[{"given":"Hongwen","family":"Liu","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong 510515 China"},{"name":"Department of Discipline Construction Office Panzhihua Central Hospital Panzhihua Sichuan 617067 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