{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:27:33Z","timestamp":1792639653597,"version":"4.5.0"},"reference-count":136,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA\u2010based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.<\/jats:p>","DOI":"10.1002\/adbi.202300621","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T22:39:56Z","timestamp":1712356796000},"source":"Crossref","is-referenced-by-count":27,"title":["Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-6904","authenticated-orcid":false,"given":"Leila","family":"Rashki Ghaleno","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology Faculty of Basic Sciences and Advanced Medical Technologies Royan Institute ACECR  Tehran 19395\u20104644 Iran"},{"name":"Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR  Tehran 19395\u20104644 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Pablo","family":"Pennisi","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg 9260 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-4586","authenticated-orcid":false,"given":"Abdolhossein","family":"Shahverdi","sequence":"additional","affiliation":[{"name":"Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR  Tehran 19395\u20104644 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-0147","authenticated-orcid":false,"given":"Fereshteh","family":"Dardmeh","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg 9260 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-4208","authenticated-orcid":false,"given":"Hiva","family":"Alipour","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg 9260 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-8243","authenticated-orcid":false,"given":"Mojtaba","family":"Rezazadeh Valojerdi","sequence":"additional","affiliation":[{"name":"Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR  Tehran 19395\u20104644 Iran"},{"name":"Department of Anatomy Faculty of Medical Sciences Tarbiat Modares University  Tehran 14115\u2013111 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00192"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-001-0377-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.03.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.020461"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_140_18"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117066"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-908"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115570906"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12741"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200372"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201700154"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12249.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624427"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3804fje"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)75338-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.11.066"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(77)90010-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100037200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.25085"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.10.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.12.019"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12081800"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6982"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31073"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.067"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2006.05.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155420929772"},{"key":"e_1_2_9_29_1","first-page":"78","volume":"28","author":"Litwiniuk M.","year":"2016","journal-title":"Wounds"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/346972"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00166-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-07-0377"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6356.2004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24939"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904701013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2020.10.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sm06463d"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342200"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.10.028"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417726464"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.04.018"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201201698"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.04.031"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01133"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2017.71"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.10.054"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127147"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.147"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1741072"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803578105"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90400-5"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-011-0093-6"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0495-3"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0464"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20971"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.3.707"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.011577"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010283"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-23-0337"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00906-5"},{"key":"e_1_2_9_61_1","first-page":"205","volume":"110","author":"Sato E.","year":"2005","journal-title":"Ital J Anat Embryol"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.2741\/A895"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109392"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2224-y"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1992.tb02638.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00402-3"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56709-0"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113504467"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80558-9"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1804.04016"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102553"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(01)00095-X"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199498000021"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2000.tb02118.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/014850101316901325"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199499000593"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_44_19"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/841615"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.2.295"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.220008nz"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000800013"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200609000-00012"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaz011"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0296"},{"key":"e_1_2_9_85_1","first-page":"131","volume":"13","author":"Ozbilgin K.","year":"2012","journal-title":"J Reprod Infertil"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoz033"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00402-3"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081266"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gax053"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20170002"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9479-3"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439530"},{"key":"e_1_2_9_93_1","first-page":"139","volume":"22","author":"Avalos\u2010Duran G.","year":"2018","journal-title":"JBRA Assist Reprod"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac058"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.09.022"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/dna2030011"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12982"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00809-8"},{"key":"e_1_2_9_99_1","volume":"9","author":"Heymann D.","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab004"},{"key":"e_1_2_9_101_1","volume":"14","author":"Karadbhajne P.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-006-9031-7"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.060"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3541-9"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2017.12.002"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0202"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2015.0069"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-29"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-119"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.120175mz"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0240"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.057"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.03.032"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-01019-9"},{"key":"e_1_2_9_115_1","first-page":"49","volume":"22","author":"Jamalzaei P.","year":"2020","journal-title":"Cell J."},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02724-3"},{"key":"e_1_2_9_117_1","first-page":"97","volume":"34","author":"Tavana S.","year":"2016","journal-title":"Groundwater"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/11\/5\/055006"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2015.0021"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.09.015"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151572"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.140"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-021-02877-9"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-022-10024-6"},{"key":"e_1_2_9_125_1","first-page":"1","volume":"38","author":"Viana J.","year":"2023","journal-title":"Embryo Technol Newsletter"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skac091"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)80077-1"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.21608\/jappmu.2022.145223.1043"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199402004057"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.4.1165"},{"key":"e_1_2_9_131_1","volume":"11","author":"Lee J.","year":"2021","journal-title":"Animals"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.08.001"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.007716"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.11.007"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223753"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.06.026"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202300621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:17:34Z","timestamp":1759425454000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202300621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":136,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/adbi.202300621"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202300621","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"article-number":"2300621"}}